Vascular-targeted photothermal therapy of an orthotopic murine glioma model.

Nanomedicine
Emily S DayJennifer L West

Abstract

To develop nanoshells for vascular-targeted photothermal therapy of glioma. The ability of nanoshells conjugated to VEGF and/or poly(ethylene glycol) (PEG) to thermally ablate VEGF receptor-2-positive endothelial cells upon near-infrared laser irradiation was evaluated in vitro. Subsequent in vivo studies evaluated therapy in mice bearing intracerebral glioma tumors by exposing tumors to near-infrared light after systemically delivering saline, PEG-coated nanoshells, or VEGF-coated nanoshells. The treatment effect was monitored with intravital microscopy and histology. VEGF-coated but not PEG-coated nanoshells bound VEGF receptor-2-positive cells in vitro to enable targeted photothermal ablation. In vivo, VEGF targeting doubled the proportion of nanoshells bound to tumor vessels and vasculature was disrupted following laser exposure. Vessels were not disrupted in mice that received saline. The normal brain was unharmed in all treatment and control mice. Nanoshell therapy can induce vascular disruption in glioma.

References

Aug 12, 1971·The New England Journal of Medicine·J Folkman
Jan 11, 2001·The New England Journal of Medicine·L M DeAngelis
Nov 5, 2003·Proceedings of the National Academy of Sciences of the United States of America·L R HirschJ L West
Dec 6, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ralf ErberPeter Vajkoczy
Feb 11, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Haralambos Gavras
May 26, 2004·Cancer Letters·D Patrick O'NealJennifer L West
Feb 9, 2006·Journal of the American Chemical Society·Xiaohua HuangMostafa A El-Sayed
Jul 25, 2006·Critical Reviews in Oncology/hematology·J TuettenbergP Vajkoczy
Aug 1, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Takuro NiidomeYasuro Niidome
Nov 24, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·G Ramachandra ReddyBrian D Ross
Jan 31, 2007·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Xiaolei ZhuChirag R Parikh
Jun 19, 2007·Cancer Research·Nabil AhmedStephen Gottschalk
Aug 29, 2007·International Journal of Nanomedicine·Amanda R LoweryJennifer L West
Mar 21, 2008·Expert Opinion on Biological Therapy·David A ReardonJames J Vredenburgh
Jul 9, 2008·Proceedings of the National Academy of Sciences of the United States of America·Eric A MurphyDavid A Cheresh
Sep 27, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Yu-Fen HuangWeihong Tan
Oct 22, 2008·Expert Review of Neurotherapeutics·Marc C Chamberlain
Feb 4, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Wei LuChun Li
Apr 2, 2009·Expert Opinion on Therapeutic Targets·Hrvoje MileticRolf Bjerkvig
Jul 31, 2009·Journal of Biomechanical Engineering·Emily S DayJennifer L West
Jan 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·Chung Hang J ChoiMark E Davis
Mar 11, 2010·Breast Cancer Research and Treatment·Laura B CarpinRebekah A Drezek
Oct 20, 2010·International Journal of Nanomedicine·Emily S DayJennifer L West
Nov 27, 2010·Journal of Neuro-oncology·Emily S DayJennifer L West
Jan 8, 2011·Small·Laura C KennedyRebekah A Drezek
Feb 16, 2011·Proceedings of the National Academy of Sciences of the United States of America·Olivier KeunenSimone P Niclou

❮ Previous
Next ❯

Citations

Sep 21, 2013·ACS Nano·Jon S DonnerRomain Quidant
Jul 19, 2013·Nature Reviews. Cancer·Muhammad H Zaman
Feb 27, 2014·Biotechnology & Genetic Engineering Reviews·Fiona WegmanJacqueline Alblas
May 15, 2013·Future Cardiology·Alexander N Kharlamov
Nov 22, 2014·Nanomedicine·Chenchen BaoJesus M de la Fuente
Sep 27, 2014·Chemical Reviews·Liang ChengZhuang Liu
Apr 19, 2015·Nanomedicine : Nanotechnology, Biology, and Medicine·Xuan ZhangJay L Nadeau
Jan 20, 2015·Nanomedicine·Feng Chen, Weibo Cai
Jun 9, 2016·Advanced Drug Delivery Reviews·Miles A Miller, Ralph Weissleder
Jun 13, 2016·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Henry Hirschberg, Steen J Madsen
Mar 29, 2019·Journal of Biomedical Materials Research. Part a·Danielle M ValcourtEmily S Day
Oct 24, 2013·Nature Materials·Jeffrey A Hubbell, Robert Langer
Jan 28, 2018·Artificial Cells, Nanomedicine, and Biotechnology·Salman BagheriHamid Kooshki
Nov 27, 2019·Cancers·Jenna C HarrisEmily S Day
Jul 17, 2020·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Georgios P SkandalakisConstantinos G Hadjipanayis
Jan 18, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Anna GraczykArkadiusz Chworos
Jun 3, 2016·Bioengineering & Translational Medicine·Aaron C Anselmo, Samir Mitragotri
Nov 21, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jinping Wang, Nan Li
Jan 1, 2013·SAGE Open Medicine·Gopalakrishna Pillai, Maria L Ceballos-Coronel
Jul 1, 2020·International Journal of Molecular Sciences·Gabriel Nery de Albuquerque RegoLionel Fernel Gamarra
Jan 23, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Duoyi ZhaoXuesi Chen
Feb 2, 2021·Frontiers in Oncology·Chiara BastiancichMarie-Anne Estève
Sep 10, 2018·Molecular Therapy. Nucleic Acids·Jilian R MelamedEmily S Day
Dec 20, 2013·Science Translational Medicine·Edward Kai-Hua Chow, Dean Ho

❮ Previous
Next ❯

Methods Mentioned

BETA
Scanning electron microscopy
electrophoresis
ELISA
Fluorescence microscopy
light
bioluminescence imaging
dynamic light scattering
light-scattering

Software Mentioned

ImageJ

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.