Vascularised fibula graft inlaid in a massive bone allograft: considerations on the bio-mechanical behaviour of the combined graft in segmental bone reconstructions after sarcoma resection

Injury
Massimo CerusoMarco Manfrini

Abstract

Vascularised fibula transfer (VFT) is a trustworthy procedure in the reconstruction of skeletal defects secondary to several pathological conditions. Over the last 20 years, progress in diagnosis in skeletal oncology and in adjuvant therapy has increased the possibility of applying limb-saving procedures in the treatment of bone sarcoma. In this context, VFT appeared to be a valuable reconstructive tool following the wide segmental resection of the long bones of the limbs. The vascularized fibula allows for fast bone fusion. It also demonstrates a tendency of progressive hypertrophy and, in those instances in which it is associated with an avascular massive bone allograft (MBA), it induces a process of osteo-integration which enhances the biomechanical properties of a combined graft. In order to assess the progression of the morphologic and structural changes of combined bone grafts we reviewed a group of 31 bone sarcoma patients who had had tibia reconstruction with a VFT inlaid in a massive allograft. Patients had been operated on between 1994 and 2006. Ages ranged from 4 to 31 years (mean 14 years). Thirty patients had received neo-adjuvant chemotherapy. Morphological variations were investigated by means of serial X-ray and...Continue Reading

References

May 1, 1975·Plastic and Reconstructive Surgery·G I TaylorF J Ham
Jan 1, 1995·International Orthopaedics·M San Julian ArangurenJ Cañadell
Jan 1, 1997·The Journal of Bone and Joint Surgery. British Volume·R W HsuE Y Chao
Aug 24, 2001·Handchirurgie, Mikrochirurgie, plastische Chirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft für Handchirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft für Mikrochirurgie der Peripheren Nerven und Gefässe : Organ der Vereinigung der Deut·M CerusoM Manfrini
Mar 25, 2004·AJR. American Journal of Roentgenology·Marco ManfriniMario Mercuri
Apr 17, 2004·Journal of Reconstructive Microsurgery·David W Chang, Kristy L Weber
Apr 20, 2004·Journal of Reconstructive Microsurgery·Kwang Suk LeeJong Ryoon Baek

❮ Previous
Next ❯

Citations

May 17, 2011·Cell and Tissue Research·Arne BernerBernd Füchtmeier
Jan 24, 2013·Injury·Aaron W T GanRobert W H Pho
Feb 19, 2013·Journal of Orthopaedics and Traumatology : Official Journal of the Italian Society of Orthopaedics and Traumatology·Yousuf M Khira, Hamed A Badawy
Jul 29, 2009·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Pieter H J BullensPieter Buma
Dec 1, 2010·Orthopaedics & Traumatology, Surgery & Research : OTSR·B CouletM Chammas
Jul 8, 2016·Orthopaedic Surgery·Mikel San-Julian, Blanca Vazquez-Garcia
Dec 21, 2016·Clinical Orthopaedics and Related Research·Marco ManfriniDavide Donati
Jun 24, 2017·European Journal of Orthopaedic Surgery & Traumatology : Orthopédie Traumatologie·Jan Lesensky, Daniel E Prince
Oct 31, 2017·European Journal of Orthopaedic Surgery & Traumatology : Orthopédie Traumatologie·Erika RoddyMichael J Gardner
Sep 9, 2016·SpringerPlus·Qing-Yu FanZhao Li
Jun 7, 2017·European Journal of Orthopaedic Surgery & Traumatology : Orthopédie Traumatologie·Georgios N PanagopoulosPanayiotis J Papagelopoulos
Dec 7, 2018·European Journal of Orthopaedic Surgery & Traumatology : Orthopédie Traumatologie·Costantino ErraniMarco Manfrini
Feb 8, 2020·Annals of Plastic Surgery·Christopher BibboStephen J Kovach

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.