Vascularization of Irregular Retinal Pigment Epithelial Detachments in Chronic Central Serous Chorioretinopathy Evaluated With OCT Angiography

Ophthalmic Surgery, Lasers & Imaging Retina
Talisa E de CarloJay S Duker

Abstract

To assess eyes with flat, irregular retinal pigment epithelial detachments (RPEDs) associated with central serous chorioretinopathy (CSCR) for choroidal neovascularization (CNV) using optical coherence tomography angiography (OCTA). Retrospective review of OCTA images of chronic CSCR eyes with irregular RPED (group 1) and regular RPED (controls, group 2) for presence of CNV, subretinal fluid, and intraretinal fluid. Fluorescein angiography was also evaluated for CNV. CNV was detected using OCTA in 13 of 31 eyes (41.9%) in group 1 and in one of 18 eyes (5.6%) in group 2 (P = .007). Irregular RPED was a risk factor for CNV (odds ratio [OR] = 12.28; 95% CI, 1.45-104.3). There was no significant difference between detection by OCTA and FA (P = 1.0). Sensitivity and specificity of detection by OCTA were 85.7% and 95.7%, respectively. Irregular RPEDs in chronic CSCR eyes may harbor neovascularization more often than previously thought, which has implications on therapy.

References

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Citations

Nov 15, 2016·Ophthalmic Surgery, Lasers & Imaging Retina·Haiyan WangHui Cao
Feb 27, 2017·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Paulo Ricardo Chaves De OliveiraDavid Robert Chow
Mar 21, 2018·European Journal of Ophthalmology·Salomon Y CohenSarah Mrejen
Jan 15, 2019·Ophthalmic Surgery, Lasers & Imaging Retina·Peter H TangRuwan A Silva
Sep 15, 2020·Therapeutic Advances in Ophthalmology·Gideon NkrumahJay Chhablani
Sep 12, 2017·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Sibel DemirelEmin Özmert
Mar 1, 2020·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Benedikt SchwormJakob Siedlecki
Dec 6, 2017·Molecular Medicine Reports·Li YuJing-Lin Yi
Feb 13, 2021·Pharmaceuticals·Stefano Da PozzoMaurizio Battaglia Parodi
Aug 6, 2021·Journal of Ophthalmology·Mary HoFrank Lai

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