Vascularizing organogenesis: Lessons from developmental biology and implications for regenerative medicine

Current Topics in Developmental Biology
Edward Daniel, Ondine Cleaver

Abstract

Organogenesis requires tightly coordinated and patterned growth of numerous cell types to form a fully mature and vascularized organ. Endothelial cells (ECs) that line blood vessels develop alongside the growing organ, but only recently has their role in directing epithelial and stromal growth been appreciated. Endothelial, epithelial, and stromal cells in embryonic organs actively communicate with one another throughout development to ensure that the organ forms appropriately. What signals tell blood vessel progenitors where to go? How are tissues influenced by the vasculature that pervades it? In this chapter, we review the ways in which crosstalk between ECs and epithelial or stromal cells during development leads to a fully patterned pancreas, lung, or kidney. ECs in all of these organs are necessary for proper epithelial and stromal growth, but how they direct this process is organ- and time-specific, highlighting the concept of dynamic EC heterogeneity. We end with a discussion on how understanding cell-cell crosstalk during development can be applied therapeutically through the generation of transplantable miniature organ-like tissues called "organoids." We will discuss the current state of organoid technology and highli...Continue Reading

Citations

Feb 28, 2020·Experimental & Molecular Medicine·Sungjin MinSeung-Woo Cho
Jul 31, 2020·Molecular Biology of the Cell·Vivian W Tang
Jul 7, 2020·Frontiers in Physiology·Emma GordonMaike Frye
Apr 9, 2020·Frontiers in Cell and Developmental Biology·Niloofar Khoshdel RadReza Moghadasali
Aug 25, 2020·Circulation Research·Guy EelenPeter Carmeliet
Mar 17, 2020·Critical Care Clinics·Daniel D Lee, Margaret A Schwarz
Aug 3, 2021·Frontiers in Cell and Developmental Biology·Hongyu LiZhaohui Li
Mar 24, 2021·Annual Review of Biomedical Engineering·Venktesh S ShirureSteven C George
Aug 27, 2021·Bioengineering·Emilie GontranPascale Dupuis-Williams

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Single-Cell RNA Sequencing: Kidney and Organoids

Single-cell RNA sequencing of the adult human kidney transcriptome can provide molecular information about cell-specific responses to environmental variables and disease states. This information can provide a dataset to benchmark human kidney organoids. Discover the latest research on adult kidney organoids at single cell resolution here.