Vasculitis treatment - new therapeutic approaches

European Journal of Pediatrics
Michael J Dillon

Abstract

In childhood, vasculitis carries with it a not inconsequential morbidity and mortality. Current therapy is usually effective in inducing remission, but there is a penalty in terms of significant and serious side effects as well as concerns about long-term maintenance regimens. Additionally, some patients are recalcitrant to treatment and options have, hitherto, been limited in relation to alternative therapy. In view of this, novel therapeutic approaches are being explored that include the better use of long-established agents as well as the utilization of newer immunosuppressive and immunomodulatory strategies. Blockade of circulating mediators and surface receptors as well as lymphocyte depletion and immunoablation are being introduced predominantly in adults but increasingly also in children. With greater understanding of the pathogenetic mechanisms involved in the disease processes it is becoming possible to utilize much more focussed therapy for these serious and life-threatening disorders with, hopefully, a decrease in long-term morbidity and mortality as well as a diminution of drug-induced adverse effects.

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Citations

Nov 4, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Paul BroganMichael Dillon
Dec 1, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Michael J DillonPaul A Brogan
Jun 19, 2009·Rheumatology·Despina EleftheriouPaul A Brogan
May 5, 2009·Current Opinion in Rheumatology·Despina EleftheriouPaul A Brogan
Jan 11, 2012·Current Rheumatology Reports·Ezgi Deniz Batu, Seza Ozen
Mar 5, 2013·La Presse médicale·Cigdem Yildiz, Seza Ozen
Jun 11, 2009·Best Practice & Research. Clinical Rheumatology·Despina Eleftheriou, Paul A Brogan
Feb 14, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Anne-Sylvia SacriJérôme Harambat

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