Vasculometabolic and Inflammatory Effects of Aldosterone in Obesity.

The Journal of Clinical Endocrinology and Metabolism
Charlotte D C C van der HeijdenNiels P Riksen

Abstract

Not all obese individuals develop cardiovascular disease (CVD). Hyperaldosteronism is suggested to cause inflammation and metabolic dysregulation, and might contribute to CVD development in obese individuals. We aimed to investigate the association of aldosterone concentrations with inflammation, metabolic disturbances, and atherosclerosis in overweight and obese individuals. Additionally, we measured renin concentrations to investigate whether the observed effects reflected general activation of the renin-angiotensin-aldosterone system (RAAS). A cross-sectional cohort study (300-OB study) was conducted. Various inflammatory parameters, traits of the metabolic syndrome, lipidome and metabolome parameters, fat distribution, and carotid atherosclerosis were associated with plasma aldosterone and renin levels. The setting of this study was the Radboudumc (i.o. Radboudumc), the Netherlands. A total of 302 individuals with a body mass index greater than or equal to 27 kg/m2 participated. Aldosterone was associated with various markers of inflammation and metabolic dysregulation, which partly differed from the associations observed for renin. Although both were associated with inflammatory cell numbers, only renin was associated with...Continue Reading

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
nuclear magnetic resonance

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