PMID: 9438417Jan 23, 1998Paper

Vasoactive intestinal peptide enhancement of antigen-induced differentiation of a cultured line of mouse thymocytes

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
R R PankhaniyaEdward J Goetzl

Abstract

The prominence of vasoactive intestinal peptide (VIP) in rodent thymic neurons suggested that this potent mediator of T cell functions may alter developmental responses of thymocytes to T cell receptor (TCR) -dependent stimulation. CD4+8+ DPK cells derived from a thymic lymphoma of a TCR transgenic mouse respond to pigeon cytochrome C (PCC) antigen in association with distinct I-E MHC II haplotypes on antigen-presenting cells (APCs) by differentiating into CD4+8- T cells. The specific recognition of VIP by two types of homologous G-protein-coupled receptors (VIPR1 and VIPR2) on DPK cells was attributable predominantly to VIPR1 before and to VIPR2 after exposure to APCs and PCC, as assessed by quantification of the respective mRNAs. PCC-evoked differentiation of DPK cells was enhanced significantly by 1 to 100 nM VIP after 3 to 4 days. The effects of VIP analogs with VIPR type selectivity implied that VIP enhancement of differentiation of DPK cells was mediated principally by VIPR2. Differential reduction in the expression of each type of VIPR by transfection of DPK cells with plasmids encoding the respective antisense mRNAs confirmed the central role of VIPR2 in VIP-enhanced conversion to CD4+8- T cells. The suppression of DPK ...Continue Reading

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Citations

Dec 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Julia K VoiceEdward J Goetzl
Dec 14, 2011·Cell and Tissue Research·Fabricio Andrés ViglianoMaría Isabel Quiroga
Jan 15, 2019·Current Pharmaceutical Design·Orhan Tansel Korkmaz, Neşe Tunçel
Aug 19, 2000·Endocrine Reviews·W Savino, M Dardenne
Feb 24, 2001·Annals of the New York Academy of Sciences·G DorsamE J Goetzl
Jul 19, 2011·World Journal of Biological Chemistry·Glenn Paul DorsamSandeep Batra
Apr 5, 2005·Current Eye Research·Shay-Whey KohEve Higginbotham
Nov 2, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J K VoiceE J Goetzl
Jun 1, 2004·Pharmacological Reviews·Mario DelgadoDoina Ganea
Feb 11, 1999·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·N Jabrane-FerratA E Goetzl
Jul 2, 2002·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·Doina Ganea, Mario Delgado
Feb 13, 2002·Drug Discovery Today·Alan WiseStephen Rees

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