Vasoactive intestinal peptide induces CD4+,CD25+ T regulatory cells with therapeutic effect in collagen-induced arthritis

Arthritis and Rheumatism
Elena Gonzalez-ReyMario Delgado

Abstract

CD4+,CD25+ T regulatory cells (Treg) control the immune response to a variety of antigens, including self antigens, and may offer opportunities to intervene in the course of autoimmune diseases. Several models support the idea of the peripheral generation of CD4+,CD25+ Treg from CD4+,CD25- T cells, but little is known about the endogenous factors and mechanisms controlling the peripheral expansion of CD4+,CD25+ Treg. We undertook this study to investigate the capacity of the vasoactive intestinal peptide (VIP), an immunosuppressive antiarthritic neuropeptide, to induce functional Treg in vivo during the development of collagen-induced arthritis (CIA). We measured the number of CD4+,CD25+ Treg following VIP administration to CIA mice, and we characterized their phenotype and their ability to suppress activation of autoreactive T cells. We determined the capacity of VIP to induce Treg in vitro as well as the use of Treg in the treatment of CIA, measuring the clinical evolution and the inflammatory and autoimmune components of the disease. The administration of VIP to arthritic mice resulted in the expansion of CD4+,CD25+,Foxp3+ Treg in the periphery and joints, which inhibited autoreactive T cell activation/expansion. VIP induced...Continue Reading

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Citations

Nov 28, 2007·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Doina GaneaMario Delgado
Dec 4, 2013·Expert Reviews in Molecular Medicine·Anne M Pesenacker, Lucy R Wedderburn
Dec 23, 2006·Nature Reviews. Immunology·Elena Gonzalez-ReyMario Delgado
May 14, 2010·Rheumatology·Ellen J WehrensBerent J Prakken
Feb 9, 2012·Cold Spring Harbor Perspectives in Medicine·R Lee MosleyHoward E Gendelman
Mar 17, 2010·Molecular and Cellular Biology·Per Anderson, Elena Gonzalez-Rey
Nov 21, 2007·Annals of the Rheumatic Diseases·Elena Gonzalez-ReyMario Delgado
Jul 8, 2011·Neuroendocrinology·Luciana Souza-MoreiraElena Gonzalez-Rey
Apr 20, 2007·Arthritis Research & Therapy·Anette KnedlaUlf Müller-Ladner
Jan 11, 2014·PloS One·Carmen MartínezIsidoro González-Álvaro
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Nov 19, 2011·Expert Review of Neurotherapeutics·Jessica A L Hutter-SaundersHoward E Gendelman
Mar 22, 2007·Expert Opinion on Biological Therapy·Nieves VarelaMario Delgado
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May 1, 2009·Human Immunology·Mario Delgado
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Feb 1, 2007·Arthritis and Rheumatism·Stanford L Peng
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Jun 17, 2008·Journal of Cellular and Molecular Medicine·Per Anderson, Mario Delgado
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Jun 27, 2013·Human Immunology·Marielle Valério CorrêaCristiane Alves da Silva Menezes

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