Vasoactive intestinal peptide induces vascular endothelial growth factor production in human HaCaT keratinocytes via MAPK pathway

Neuropeptides
Xiao-Jing YuChun-Yang Li

Abstract

Psoriasis is a chronic skin disease characterized by abnormal keratinocyte proliferation and differentiation, inflammation, and angiogenesis. Although dysfunction of the immune system is known to be an important factor in the pathogenesis of psoriasis, there is also strong evidence that psychological stresses are involved. Neuropeptides are thought to be main mediators of neurogenic inflammation, presumably involved in the pathogenesis of psoriasis. Vasoactive intestinal peptide (VIP) is one of the major neuropeptides in human and rodent skin. In the present study, we examined the effect and mechanism of VIP on vascular endothelial growth factor (VEGF) production by HaCaT cells which is a spontaneous, immortalized, human keratinocyte cell line. Our data indicate the mRNA and protein levels of VEGF by VIP were increased in a concentration-dependent manner. However, this increase was abrogated by pretreatment with an extracellular signal-regulated kinase (ERK) inhibitor PD98059 or p38MAPK inhibitor SB203580; pretreatment with c-Jun N-terminal kinase (JNK) inhibitor SP600125 did not attenuate the effects of VIP on the expression of VEGF. In addition, VIP treatment induced rapid phosphorylation of ERK1/2 and p38MAPK, and PD98059 an...Continue Reading

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Citations

Jan 26, 2012·Neurotoxicity Research·Li ZhangDezhi Mu
Jan 17, 2015·Biomolecules & Therapeutics·Ok-Nam BaeTae Cheon Jeong
Aug 5, 2011·Journal of Cellular Biochemistry·Emma Persson, Ulf H Lerner
Oct 19, 2013·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Jérémy ChéretChristelle Le Gall-Ianotto
Jun 4, 2014·Experimental Dermatology·Andrzej T SlominskiRobert C Tuckey
Jan 19, 2020·Experimental Dermatology·Marissa T AyasseMartin Steinhoff
Apr 8, 2020·Cells·Manel B HammoudaJennifer Y Zhang
Oct 7, 2021·British Journal of Clinical Pharmacology·Gonjin SongHye Sun Gwak

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