PMID: 6103537Mar 1, 1980Paper

Vasoactive intestinal polypeptide in cholinergic neurons of exocrine glands: functional significance of coexisting transmitters for vasodilation and secretion

Proceedings of the National Academy of Sciences of the United States of America
J M LundbergV Mutt

Abstract

By a combination of the indirect immunofluorescence technique with acetylcholinesterase (acetylcholine acetylhydrolase, EC 3.1.1.7) staining, it was shown that vasoactive intestinal polypeptide (VIP) is present in cholinergic (acetylcholinesterase-rich) neurons involved in control of secretion and vasodilation in exocrine glands of cat. The submandibular salivary gland was used as a functional model. Preganglionic nerve stimulation induced an atropine-resistant, hexamethonium-sensitive vasodilation and release of VIP into the venous outflow from the gland and an atropine- and hexamethonium-sensitive secretion. Infusion of VIP antiserum reduced both the vasodilation and secretion. Infusion of VIP caused vasodilation only, whereas acetylcholine caused both vasodilation and secretion. Simultaneous infusion of VIP and acetylcholine in low doses resulted in a marked potentiation of both vasodilation and secretion. The present morphological and functional data support the following hypothesis for regulation of vasodilation and secretion in exocrine glands. Preganglionic cholinergic nerves activate, via nicotinic receptors, postganglionic neurons, causing concomitant release from the same nerve endings of two coexisting putative trans...Continue Reading

References

Aug 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·A GiachettiF C Koniges
Jan 1, 1978·General Pharmacology·K NustadJ V Pierce
Dec 1, 1978·Journal of Neurochemistry·J Fahrenkrug, O B Schaffalitzky de Muckadell
Mar 2, 1978·Histochemistry·F SundlerO Schaffalitzky de Muckadell
Mar 1, 1978·Life Sciences·L I LarssonO B Schaffalitzky de Muckadell
Jul 1, 1978·British Journal of Pharmacology·T Shimizu, N Taira
Jan 1, 1978·Scandinavian Journal of Gastroenterology·O B Schaffalitzky de MuckadellH Worning
Sep 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·L I LarssonJ R Rehfeld
Feb 25, 1977·Brain Research·V M PickelS E Leeman
Apr 1, 1977·Brain Research·J FahrenkrugA Fahrenkrug
Oct 1, 1976·British Journal of Pharmacology·S H Ferreira, L H Smaje
Jan 1, 1969·Journal of Neuro-visceral Relations·K A NorbergC M Eneroth
Dec 1, 1967·Acta Physiologica Scandinavica·G BuckleyF Sjöqvist
Apr 1, 1967·Acta Physiologica Scandinavica·E GiacobiniF Sjöqvist
Jan 1, 1959·The American Journal of Anatomy·B L SCOTT, D C PEASE

❮ Previous
Next ❯

Citations

Jan 1, 1985·Cell and Tissue Research·P BałukS Matsuda
Jan 1, 1995·Cell and Tissue Research·M LidegranS Forsgren
Jan 1, 1990·European Journal of Applied Physiology and Occupational Physiology·J SugenoyaT Ogawa
Jan 1, 1996·European Journal of Applied Physiology and Occupational Physiology·Y Inoue, M Shibasaki
Apr 1, 1996·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·P SeifertE Weihe
Jan 1, 1983·Archives of Oto-rhino-laryngology·R UddmanF Sundler
Jan 1, 1987·Histochemistry·S Tsukahara, D M Jacobowitz
Jan 1, 1995·European Journal of Applied Physiology and Occupational Physiology·J SugenoyaK Natsume
Nov 1, 1987·Pflügers Archiv : European journal of physiology·M A Kolka, L A Stephenson
Feb 1, 1983·Pflügers Archiv : European journal of physiology·I M Lang, M F Tansy
Jan 1, 1989·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·J LehtosaloA Palkama
Apr 1, 1997·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·K KumazawaT Ogawa
Sep 8, 2010·Naunyn-Schmiedeberg's Archives of Pharmacology·Chung-Hung ShihWun-Chang Ko
Jan 1, 1989·Pharmacology & Therapeutics·J Fahrenkrug
Jan 1, 1990·Pharmacology & Therapeutics·M C MioneG Burnstock
Jan 1, 1985·Journal of Affective Disorders·W H BerrettiniE S Gershon
May 1, 1983·Journal of the Autonomic Nervous System·C Bell
Jan 1, 1983·Journal of the Autonomic Nervous System·O H Viveros, S P Wilson
Jun 1, 1983·Journal of the Autonomic Nervous System·B E Slack, J W Downie
Apr 1, 1986·Journal of the Autonomic Nervous System·W G DailK Manzanares
Apr 1, 1994·Journal of the Autonomic Nervous System·R M WilliamsK A Sharkey
Jan 1, 1984·Annales d'endocrinologie·G Pelletier

❮ Previous
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