PMID: 3748848Jan 1, 1986Paper

Vasoactive intestinal polypeptide relaxes pulmonary artery by an endothelium-independent mechanism

Peptides
T SataS I Said

Abstract

Vasoactive intestinal polypeptide (VIP) is a potent endogenous vasodilator. VIP-induced vasodilation is independent of adrenergic or cholinergic receptors and, for the most part, of arachidonate metabolites, but its mechanism is still unknown. In view of the recently demonstrated essential role of endothelium in the relaxant effect of numerous vasodilators, we have investigated the importance of endothelium in the vascular relaxation induced by VIP. Vascular smooth muscle preparations were circular strips of the pulmonary artery of guinea pig, rat and rabbit, and rat thoracic aorta, previously contracted by a synthetic prostaglandin endoperoxide analog. VIP relaxed pulmonary artery of all species by an endothelium-independent mechanism, but relaxed rat thoracic aorta only in the presence of intact endothelium.

References

Feb 26, 1985·European Journal of Pharmacology·P Schoeffter, J C Stoclet
Mar 12, 1982·European Journal of Pharmacology·S P Duckles, S I Said
Jan 1, 1984·Annual Review of Pharmacology and Toxicology·R F Furchgott
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Mar 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·P D CherryD Jothianandan
Jan 1, 1982·Acta paediatrica Scandinavica·A LucasA Aynsley-Green

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Citations

Aug 10, 2010·The Journal of Physiological Sciences : JPS·Shuang ZhangDaling Zhu
Jun 8, 1990·European Journal of Pharmacology·H ItohO P Rorstad
Apr 1, 1991·Clinical and Experimental Pharmacology & Physiology·M J LeroyF Ferré
Jun 1, 1992·British Heart Journal·T N LuuM H Yacoub
Nov 16, 2013·Rejuvenation Research·Donato LacedoniaMaria Pia Foschino Barbaro
Dec 1, 1987·The American Review of Respiratory Disease·N W Bunnett
Dec 19, 2006·Regulatory Peptides· Anaid ShahbazianWilhelm Mosgoeller
Jan 1, 1988·Annals of the New York Academy of Sciences·T C SmithermanS I Said
Jan 1, 1988·Annals of the New York Academy of Sciences·S I Said
May 16, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Sami I Said

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