PMID: 6986955Mar 17, 1980Paper

Vasoactive intestinal polypeptide (VIP) in mouse and rat brain: an immunocytochemical study

Brain Research
K B SimsE A Zimmerman

Abstract

Immunoperoxidase technique and light microscopy were used to investigate the distribution of vasoactive intestinal polypeptide (VIP) in mouse and rat brain. Both 50 micrometers unmounted cryostat and 6 micrometers deparaffinized sections were studied in coronal or sagittal plane. At least 4 different major VIP systems were found: (1) an intracerebral cortical system; (2) one innervating the central amygdala and nucleus of the stria terminalis; (3) a pathway originating in the suprachiasmatic nucleus of the hypo thalamus; and (4) another originating in the central grey of the midbrain. Specific cell body staining was seen in the limbic and neocortex, in the basal-caudal portion of the suprachiasmatic nucleus of the hypothalamus, and in the central grey of the midbrain. Heavy terminal field patterns were noted in the suprachiasmatic nucleus, central amygdaloid nucleus, bed nucleus of the stria terminalis and nucleus accumbens. Fiber density was moderate in the tuberculum olfactoriu, anterior hypothalamus including the medial preoptic area, mediobasal hypothalamus (especially dorsomedial region), periventricular thalamus, lateral lemniscal system, parabrachial nucleus, nucleus solitarius, and area postrema. Fibers could be traced ...Continue Reading

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Citations

Jan 1, 1996·Hippocampus·T F Freund, G Buzsáki
Jan 1, 1985·Cell and Tissue Research·S DaikokuT Shibasaki
Jan 1, 1983·Anatomy and Embryology·B BaeckerW G Forssmann
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Jul 24, 1995·Brain Research·B el KafiR Cespuglio
Jan 1, 1995·Neuroscience and Biobehavioral Reviews·R F Weick, K M Stobie

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