Vasoactive peptide release in the extracerebral circulation of humans during migraine headache

Annals of Neurology
P J GoadsbyR Ekman


The innervation of the cranial vessels by the trigeminal nerve, the trigeminovascular system, has recently been the subject of study in view of its possible role in the mediation of some aspects of migraine. Since stimulation of the trigeminal ganglion in humans leads to facial pain and flushing and associated release of powerful neuropeptide vasodilator substances, their local release into the extracerebral circulation of humans was determined in patients who had either common or classic migraine. Venous blood was sampled from both the external jugular and cubital fossa ipsilateral to the side of headache. Plasma levels of neuropeptide Y, vasoactive intestinal polypeptide, substance P, and calcitonin gene-related peptide were determined using sensitive radioimmunoassays for each peptide, and values for the cubital fossa and external jugular and a control population were compared. A substantial elevation of the calcitonin gene-related peptide level in the external jugular but not the cubital fossa blood was seen in both classic and common migraine. The increase seen in classic migraine was greater than that seen with common migraine. The other peptides measured were unaltered. This finding may have importance in the pathophysio...Continue Reading


Oct 1, 1995·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·L L Thomsen, J Olesen
Oct 1, 1994·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·P D Drummond
Jun 1, 1994·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·P D DrummondP J Goadsby
Jun 29, 2005·Naunyn-Schmiedeberg's Archives of Pharmacology·Raphaela VerheggenAlberto J Kaumann
Mar 17, 2009·Experimental Brain Research·K Messlinger
Aug 10, 2012·Pflügers Archiv : European journal of physiology·Mária DuxGábor Jancsó
Nov 13, 2007·Journal of Neural Transmission·W J Schulte-Mattler, E Leinisch
Dec 17, 2010·Journal of Neural Transmission·J TajtiL Vecsei
Jan 6, 2011·Journal of Neural Transmission·Elliot Shevel
Jul 17, 2008·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Fabio FredianiGerardo Casucci
Aug 10, 2002·Current Neurology and Neuroscience Reports·Robert F Saul
Mar 17, 2001·Current Pain and Headache Reports·L Edvinsson
Feb 26, 2004·Current Pain and Headache Reports·Dale M Carter
Mar 21, 2007·Current Pain and Headache Reports·Angela M Applebee, Robert E Shapiro
Oct 12, 2010·Current Pain and Headache Reports·Teshamae S Monteith, Till Sprenger
Nov 9, 2010·Current Pain and Headache Reports·Milena De FeliceFrank Porreca
Nov 15, 2011·Current Pain and Headache Reports·Marcelo E Bigal, Alan M Rapoport
Aug 6, 2013·Current Pain and Headache Reports·Nu Cindy ChaiAlan M Rapoport
Nov 16, 2013·Current Pain and Headache Reports·Nada Ahmad HindiyehRobert Paul Cowan
Sep 14, 2004·Current Pain and Headache Reports·P J Goadsby
Dec 20, 2008·Current Treatment Options in Neurology·Mark Obermann, Hans-Christoph Diener
Nov 27, 2010·Current Treatment Options in Neurology·Teshamae S Monteith, P J Goadsby
Nov 18, 2011·Current Treatment Options in Neurology·Jan Hoffmann, P J Goadsby
Oct 4, 2002·Comprehensive Therapy·Egilius L H Spierings
May 1, 1994·Trends in Pharmacological Sciences·J OlesenH Iversen
Jan 1, 1991·Trends in Neurosciences·J Olesen, L Edvinsson
Jan 1, 1992·Clinical Neurology and Neurosurgery·M D Ferrari, P R Saxena
Jan 1, 1993·Brain Research Bulletin·J T KellerM Zuccarello


Nov 1, 1976·Headache·N H Raskin, S C Knittle
Dec 1, 1989·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·L EdvinssonT Thulin
Mar 11, 1985·Brain Research·P J Goadsby, G J MacDonald
Mar 1, 1988·Cephalalgia : an International Journal of Headache·F SorgeP Carrieri
May 1, 1987·Journal of Neurology, Neurosurgery, and Psychiatry·H SchonS R Bloom
Dec 22, 1986·Regulatory Peptides·R EkmanP Panula
Sep 1, 1987·Headache·N H RaskinS Lamb
Mar 1, 1986·Cephalalgia : an International Journal of Headache·O Sjaastad, T A Fredriksen
Aug 1, 1983·Neuroscience·L Y Liu-ChenM A Moskowitz
Sep 1, 1984·Cephalalgia : an International Journal of Headache·P D Drummond, J W Lance
Jul 1, 1983·Journal of Neurology, Neurosurgery, and Psychiatry·P D DrummondJ W Lance
Aug 1, 1984·Journal of Neurosurgery·G LambertJ W Lance
Apr 1, 1984·Journal of the Autonomic Nervous System·P J GoadsbyJ W Lance
Jan 1, 1983·Annals of Neurology·P D Drummond, J W Lance
Feb 1, 1980·Neurology·N H Raskin, R K Schwartz

Related Concepts

Migraine With Aura
Vasoactive Intestinal Peptide
Structure of Jugular Vein
Status Migrainosus
Vascular Endothelium-Dependent Relaxation
Cerebrovascular Circulation
Hypothalamic Substance P
Calcitonin Gene-Related Peptide II
Neuropeptide Y Like Immunoreactive Peptide

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Sexual Dimorphism in Neurodegeneration

There exist sex differences in neurodevelopmental and neurodegenerative disorders. For instance, multiple sclerosis is more common in women, whereas Parkinson’s disease is more common in men. Here is the latest research on sexual dimorphism in neurodegeneration

HLA Genetic Variation

HLA genetic variation has been found to confer risk for a wide variety of diseases. Identifying these associations and understanding their molecular mechanisms is ongoing and holds promise for the development of therapeutics. Find the latest research on HLA genetic variation here.

Super-resolution Microscopy

Super-resolution microscopy is the term commonly given to fluorescence microscopy techniques with resolutions that are not limited by the diffraction of light. Here are the latest discoveries pertaining to super-resolution microscopy.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.

Brain Lower Grade Glioma

Low grade gliomas in the brain form from oligodendrocytes and astrocytes and are the slowest-growing glioma in adults. Discover the latest research on these brain tumors here.

CD4/CD8 Signaling

Cluster of differentiation 4 and 8 (CD8 and CD8) are glycoproteins founds on the surface of immune cells. Here is the latest research on their role in cell signaling pathways.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.