Vasoactive properties of dihomo-gamma-linolenic acid and series one prostaglandins in a freshwater teleost, Channa maculata

Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology
N Y WooK L Yu

Abstract

1. Prostaglandins A1, B1, E1 and F1 alpha (2-120 micrograms/kg), arachidonic acid and dihomo-gamma-linolenic acid (0.1-2 mg/kg) were injected intravenously into Channa maculata and changes in arterial blood pressure were recorded. 2. Injection of PGF1 alpha had no significant effect on arterial blood pressure. Injection of PGA1 and PGE1 was followed by dose-dependent hypotension whereas injection of PGB1 elicited significant dose-dependent increase in arterial blood pressure. 3. Both dihomo-gamma-linolenic acid and arachidonic acid were also depressor agents but dihomo-gamma-linolenic acid was more potent. 4. A single bolus intravenous injection of indomethacin (5 mg/kg) or 4 daily intraperitoneal injections (4 x 10 mg/kg) significantly lowered arterial blood pressure. One hour after pre-treatment of indomethacin, the vascular effects of both prostaglandin precursors were abolished. 5. It appears that the vascular effects of prostaglandins in Channa maculata are qualitatively different from those reported for mammals.

References

Apr 22, 1976·Biochimica Et Biophysica Acta·T Nomura, H Ogata
Dec 1, 1977·The Journal of Clinical Investigation·R M ZusmanJ S Handler
Mar 1, 1979·European Journal of Pharmacology·K M MullaneJ R Vane
Apr 1, 1975·Proceedings of the Society for Experimental Biology and Medicine·J C RoseP A Kot
May 1, 1986·General and Comparative Endocrinology·N A Wales, T Gaunt
Jun 1, 1974·Canadian Journal of Physiology and Pharmacology·S GreenbergW R Wilson
Aug 11, 1972·Biochimica Et Biophysica Acta·E J Christ, D A van Dorp
Dec 1, 1974·Proceedings of the Society for Experimental Biology and Medicine·J C RoseP A Kot
Dec 8, 1972·Biochimica Et Biophysica Acta·R L JonesE W Horton
Nov 1, 1972·Prostaglandins·A P Labhsetwar
Sep 1, 1973·Proceedings of the Society for Experimental Biology and Medicine·S GreenbergW R Wilson
Nov 1, 1973·European Journal of Pharmacology·M C KossJ Nakano
Jul 1, 1972·Proceedings of the Society for Experimental Biology and Medicine·F Grande, W F Prigge
Aug 1, 1967·British Journal of Pharmacology and Chemotherapy·E W Horton, I H Main
Jan 1, 1984·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·R A GibsonG M Kneebone
Jul 1, 1982·Canadian Journal of Physiology and Pharmacology·S H CurryS Cassin

❮ Previous
Next ❯

Citations

Mar 1, 1990·The Journal of Nutritional Biochemistry·J E KinsellaJ W Whelan
May 12, 1998·The American Journal of Physiology·D H Evans, M P Gunderson
Oct 2, 1998·The American Journal of Physiology·J C Le MévelJ M Conlon

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.