PMID: 2489796Sep 1, 1989Paper

Vasoconstrictor contained in local anesthetic--its effect on body temperature and circulatory kinetics

Nichidai kōkū kagaku = Nihon University journal of oral science
H Yoshii

Abstract

Changes in body temperature and blood circulation wave been monitored to investigate the effect of some vasoconstrictor contained in a local anesthetic on living body. The results obtained are described below. Subjects selected were six healthy male students (23-29 years in age). Drugs used for the experiment were 3% tolycaine for local anesthetic added with 72 micrograms, 108 micrograms or 144 micrograms of epinephrine in epinephrine group; with 90 micrograms, 135 micrograms or 180 micrograms of norepinephrine in norepinephrine group, and with each 36 micrograms, 54 micrograms, 72 micrograms of epinephrine and 36 micrograms, 54 micrograms or 72 micrograms of norepinephrine in epinephrien + norepinephrine group. 1. Change in body temperature 1) Tympanic membrane temperature There was no significant difference between pre- and post injection values in all dose groups. 2) Average skin temperature in big toe The temperature was decreased significantly at 0-25 min. in epinephrine group, in norepinephrine group and in epinephrine + norepinephrine group, compared to that prior to injection. 2. Change in circulatory kinetics 1) Epinephrine group Heart rate and RPP was increased significantly at 0-40 min. (72 micrograms) and at 0-50 mi...Continue Reading

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