PMID: 7543980Jun 1, 1995Paper

Vasoconstrictor mechanism of neuropeptides augmented after endothelial removal in isolated, perfused canine basilar arteries

Neurological Research
T Tsuji, D A Cook

Abstract

In order to investigate the functional role of endothelium and vasoeffector mechanism in cerebrovascular responses to neuropeptides, the stainless steel cannula inserting method was applied to examine the responses to intraluminally-applied bradykinin, substance P and vasopressin in isolated and perfused canine basilar arteries. In control vessels with intact endothelium, each neuropeptide induced a monophasic dilation at lower doses, and a biphasic response, i.e., an initial dilation followed by a secondary constriction, at higher doses. The dilation was significantly reduced and the constriction was significantly enhanced, while the dilation to papaverine was not modified by endothelial removal with intraluminal saponin. The same tendency was observed in the responses after extraluminal treatment with oxyhaemoglobin. The monophasic constrictions to prostaglandin F2 alpha and potassium chloride were significantly potentiated by the endothelial removal. The augmented constrictions to the neuropeptides were significantly diminished by indomethacin (a cyclooxygenase inhibitor), OKY-046 (a thromboxane synthetase inhibitor) and nimodipine (a dihydropyridine calcium antagonist), but not by AA-861 (a lipoxygenase inhibitor). These re...Continue Reading

Citations

Feb 1, 2006·Clinical and Experimental Pharmacology & Physiology·Cristina C TrandafirKazuyoshi Kurahashi
May 17, 2014·Naunyn-Schmiedeberg's Archives of Pharmacology·Md Zahorul IslamAtsushi Miyamoto
Aug 4, 2009·Journal of Veterinary Pharmacology and Therapeutics·D UenoA Miyamoto
Apr 1, 2004·Clinical and Experimental Pharmacology & Physiology·Cristina C TrandafirKazuyoshi Kurahashi
Sep 19, 2021·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Md Zahorul IslamAtsushi Miyamoto

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