PMID: 6986224Jan 1, 1980Paper

Vasodepressor property of the converting enzyme inhibitor captopril (SQ 14 225): the role of factors other than renin-angiotensin blockade in the rat

Clinical Science
E S MarksJ D Swales

Abstract

1. The peptide converting enzyme inhibitor captopril was given (1.25 mg/kg intravenously) to normal and nephrectomized rats and rats with renovascular and deoxycorticosterone hypertension. 2. Captopril lowered blood pressure to a small extent in normal and nephrectomized rats. Bradykinin infusion in nephrectomized animals, however, potentiated the vasodepressor action of captopril. 3. Captopril produced a major blood pressure fall in the early stages of Goldblatt two-kidney one-clip hypertension: even when hypertension had been present for more than 4 months, a substantial vasodepressor action was seen. Rats with deoxycorticosterone-induced hypertension also showed a significant blood pressure fall. 4. Captopril was given to salt-loaded and salt-depleted rats in which the renin-angiotensin system had been blocked by infusion of the competitive angiotensin II antagonist saralasin. Captopril still lowered blood pressure in the salt-depleted group. 5. Captopril lowers blood pressure in situations where the renin-angiotensin system is not responsible for blood pressure maintenance. Further, the fall in blood pressure produced in Goldblatt two-kidney one-clip hypertension is greater than would be predicted on the basis of renin-angi...Continue Reading

Citations

Jan 1, 1983·Clinical and Experimental Hypertension. Part A, Theory and Practice·H HashimotoT Kokubu
Jan 1, 1983·Clinical and Experimental Hypertension. Part A, Theory and Practice·J D SwalesH Thurston
Jan 1, 1983·Clinical and Experimental Hypertension. Part A, Theory and Practice·O A CarreteroA G Scicli
Apr 1, 1986·Clinical and Experimental Pharmacology & Physiology·J ZhuoS L Skinner
Sep 1, 1991·Hypertension·O A Carretero, A G Scicli
May 1, 1988·Hypertension·M Nakagawa, A Nasjletti
Nov 3, 2005·American Journal of Physiology. Renal Physiology·Patrick K K LeongAlicia A McDonough
Oct 25, 2012·Ecological Applications : a Publication of the Ecological Society of America·Frank J ShaughnessyMark Petrie
Jun 18, 2014·Ecology·Philip A StephensJohn M McNamara
May 4, 2007·The Journal of Pharmacology and Experimental Therapeutics·Danielle IanzerAntônio Carlos Martins de Camargo
Oct 7, 1982·Nature·M SzelkeA F Lever
May 1, 1985·Journal of the Royal Society of Medicine·M S LaherT B Counihan
Aug 1, 1989·Journal of the American Geriatrics Society·J E HallA C Guyton
May 1, 1986·British Journal of Clinical Pharmacology·A A AjayiJ L Reid
Jan 1, 1989·Pharmacotherapy·M R UjhelyiP H Vlasses
Mar 1, 1988·British Journal of Clinical Pharmacology·G B KondoweD W Harron
Sep 14, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Patrick K K LeongAlicia A McDonough
Nov 1, 2020·Pharmaceuticals·Suhail HamidNour-Eddine Rhaleb
Apr 1, 1985·Pharmacological Research Communications·F M Santoro, I J de la Riva

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.