PMID: 6986224Jan 1, 1980Paper

Vasodepressor property of the converting enzyme inhibitor captopril (SQ 14 225): the role of factors other than renin-angiotensin blockade in the rat

Clinical Science
E S MarksJ D Swales

Abstract

1. The peptide converting enzyme inhibitor captopril was given (1.25 mg/kg intravenously) to normal and nephrectomized rats and rats with renovascular and deoxycorticosterone hypertension. 2. Captopril lowered blood pressure to a small extent in normal and nephrectomized rats. Bradykinin infusion in nephrectomized animals, however, potentiated the vasodepressor action of captopril. 3. Captopril produced a major blood pressure fall in the early stages of Goldblatt two-kidney one-clip hypertension: even when hypertension had been present for more than 4 months, a substantial vasodepressor action was seen. Rats with deoxycorticosterone-induced hypertension also showed a significant blood pressure fall. 4. Captopril was given to salt-loaded and salt-depleted rats in which the renin-angiotensin system had been blocked by infusion of the competitive angiotensin II antagonist saralasin. Captopril still lowered blood pressure in the salt-depleted group. 5. Captopril lowers blood pressure in situations where the renin-angiotensin system is not responsible for blood pressure maintenance. Further, the fall in blood pressure produced in Goldblatt two-kidney one-clip hypertension is greater than would be predicted on the basis of renin-angi...Continue Reading

Citations

Jan 1, 1983·Clinical and Experimental Hypertension. Part A, Theory and Practice·H HashimotoT Kokubu
Jan 1, 1983·Clinical and Experimental Hypertension. Part A, Theory and Practice·J D SwalesH Thurston
Jan 1, 1983·Clinical and Experimental Hypertension. Part A, Theory and Practice·O A CarreteroA G Scicli
Apr 1, 1986·Clinical and Experimental Pharmacology & Physiology·J ZhuoS L Skinner
Sep 1, 1991·Hypertension·O A Carretero, A G Scicli
May 1, 1988·Hypertension·M Nakagawa, A Nasjletti
Nov 3, 2005·American Journal of Physiology. Renal Physiology·Patrick K K LeongAlicia A McDonough
Oct 25, 2012·Ecological Applications : a Publication of the Ecological Society of America·Frank J ShaughnessyMark Petrie
Jun 18, 2014·Ecology·Philip A StephensJohn M McNamara
May 4, 2007·The Journal of Pharmacology and Experimental Therapeutics·Danielle IanzerAntônio Carlos Martins de Camargo
Oct 7, 1982·Nature·M SzelkeA F Lever
May 1, 1985·Journal of the Royal Society of Medicine·M S LaherT B Counihan
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May 1, 1986·British Journal of Clinical Pharmacology·A A AjayiJ L Reid
Jan 1, 1989·Pharmacotherapy·M R UjhelyiP H Vlasses
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Sep 14, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Patrick K K LeongAlicia A McDonough
Nov 1, 2020·Pharmaceuticals·Suhail HamidNour-Eddine Rhaleb

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