Vasodilatation and modulation of vasoconstriction in canine subcutaneous adipose tissue caused by activation of beta-adrenoceptors

Acta Physiologica Scandinavica
E Belfrage

Abstract

The present experiments were undertaken to study the balance between vascular alpha- and beta-adrenoceptors in canine subcutaneous adipose tissue during sympathetic nerve stimulation and noradrenaline injections. Propranolol potentiated and prolonged the vasoconstrictor response to close i.a. injections of noradrenaline. The vasoconstriction induced by brief nerve stimulation (0.5 to 8 Hz) was, however, unaltered by the beta-adrenoceptor blockade. During prolonged nerve stimulation the vasoconstrictor response was well maintained at 1.5 Hz but at 4 Hz there was a gradual escape. The escape phenomenon at 4 Hz was diminished by propranolol. The beta1-selective antagonist practolol, like propranolol, potentiated and prolonged the vasoconstriction induced by noradrenaline injections and reduced the vasoconstrictor escape during prolonged nerve stimulation at 4 Hz. Furthermore, the vasodilatation induced by noradrenaline injection or nerve stimulation during alpha-adrenoceptor blockade was diminished by practolol. Practolol also blocked the lipolytic response to noradrenaline and nerve stimulation. The beta2-selective antagonist H35/25 blocked the effects of the beta2-selective agonist salbutamol but failed to alter noradrenaline as...Continue Reading

References

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Citations

Jan 1, 1980·Tissue & Cell·J R Casley-Smith, A H Vincent
Jan 1, 1983·General Pharmacology·P HjemdahlE Belfrage
Feb 1, 1981·Acta Physiologica Scandinavica·K SkagenF Bonde-Petersen
May 1, 1990·The Journal of Pharmacy and Pharmacology·J M PoirierF C Hugues
Nov 1, 1984·The American Journal of Emergency Medicine·A Heath
Feb 1, 1981·British Journal of Pharmacology·B CarlsööL A Idahl
Jan 30, 2019·The Journal of Physiology·Asger Maare SøndergaardChristian Aalkjær
Jan 1, 1982·Acta Medica Scandinavica. Supplementum·L EkB Johansson
Jan 1, 1979·Acta Pharmacologica Et Toxicologica·E Carlsson
Jan 1, 1982·British Journal of Clinical Pharmacology·H H HarmsJ Zaagsma
Jan 1, 1982·Acta Medica Scandinavica. Supplementum·T AnderssonH Mattsson
Jan 9, 2021·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Søren GrubbChristian Aalkjær

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