PMID: 6162493Jan 1, 1981Paper

Vasodilatation augments the blood-brain barrier lesions induced by an acute rise in intracarotid pressure

Blood Vessels
J E Hardebo

Abstract

The vessel wall tension is the product of pressure and internal radius divided by the vessel wall thickness. Hence, dilated vessels will be exposed to higher tension at a given intraluminal pressure. Provided the rise in cerebrovascular intraluminal pressure is sufficiently prominent, transient opening of the morphologic blood-brain barrier will occur. In the present study pressure increase, not sufficient in itself to cause barrier opening, was induced. However, at concomitant dilatation of the vessels--as induced by CO2 or papaverine--under otherwise identical pressure conditions a barrier opening was obtained. Hence, vasodilatation of cerebral vessels will increase their vulnerability to hypertension.

Citations

Feb 1, 1994·Acta Anaesthesiologica Scandinavica·A WesterlindB Ekström-Jodal
Jan 1, 1981·Acta Physiologica Scandinavica·J E Hardebo, B Nilsson
Nov 1, 1985·Acta Physiologica Scandinavica·J E Hardebo, J Kåhrström
Nov 1, 2008·The European Journal of Neuroscience·Samuel TétraultFlorin Amzica

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