PMID: 11927685Apr 3, 2002Paper

Vasodilatation in response to repeated anodal current application in the human skin relies on aspirin-sensitive mechanisms

The Journal of Physiology
S DurandP Abraham

Abstract

The vasodilatation resulting from prolonged square-wave monopolar current application as used in iontophoresis is assumed to rely on an axon reflex. Involvement of prostaglandins in the anodal current-induced vasodilatation remains unclear. We tested the hypothesis that prostaglandins participate in a sensitisation mechanism to current application rather than as direct vasodilators. In healthy volunteers, laser Doppler flowmetry (LDF) was recorded in the forearm during and following isolated or repeated 0.1 mA transcutaneous anodal current applications, using deionised water as a vehicle. Segmented current applications of 6 or 12 mC resulted in an LDF increase twice that observed following current applications of comparable total charge delivered all at once (P < 0.05). Following a 1 min anodal application, a slow and prolonged LDF drift occurred (slope: 0.3 +/- 0.5 arbitrary units min(-1)). When the same current application was repeated after intervals of 5 and 20 min, an abrupt vasodilatation occurred, with maximal LDF amplitude of 53.5 +/- 34.0 and 48.2 +/- 19.1 arbitrary units, respectively. Pretreatment with 1 g oral aspirin abolished the abrupt vasodilatation to repeated current application but not the initial slow drift....Continue Reading

References

Oct 1, 1978·The Journal of Investigative Dermatology·O HägermarkB Pernow
Aug 1, 1986·Clinical Physiology·J M JohnsonW Kosiba
Jul 1, 1984·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·W F TaylorM K Park
Mar 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·V LabhasetwarR J Levy
Apr 1, 1994·Journal of Applied Physiology·M V Savage, G L Brengelmann
Feb 7, 1998·American Journal of Physical Medicine & Rehabilitation·M N Berliner
Aug 1, 1997·The Journal of Investigative Dermatology. Symposium Proceedings·J Wallengren
Jul 29, 1999·European Journal of Clinical Pharmacology·M GrossmannW Kirch
Mar 16, 2000·Neuroreport·M SchmelzH O Handwerker

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Citations

Jul 19, 2012·Medical & Biological Engineering & Computing·Anne Humeau-HeurtierGuillaume Mahé
May 29, 2010·Journal of Applied Physiology·Christopher T Minson
Jul 12, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Charlotte J StaggIrene Tracey
Dec 21, 2013·Journal des maladies vasculaires·C PuissantG Mahé
Oct 1, 2013·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Shapour JaberzadehMaryam Zoghi
Dec 15, 2015·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·A J WoodsM A Nitsche
Feb 19, 2013·Brain Stimulation·Narong AuvichayapatParadee Auvichayapat
Nov 6, 2012·Microvascular Research·Jill J F BelchFaisel Khan
Oct 12, 2011·Brain Stimulation·Philipp RiedelKatharina von Kriegstein
Sep 10, 2010·The Journal of Investigative Dermatology·Stéphanie GohinBérengère Fromy
Jul 25, 2015·Microvascular Research·Stéphanie GohinBérengère Fromy
Jul 1, 2008·Brain Stimulation·Michael A NitscheAlvaro Pascual-Leone
Apr 25, 2007·Microvascular Research·A RousseauF Sjöberg
Sep 3, 2011·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Matthieu Roustit, Jean-Luc Cracowski
Mar 23, 2011·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Jean-Luc Cracowski
Mar 1, 2006·Journal of Diabetes and Its Complications·Jean-Luc CracowskiChristopher T Minson
Mar 11, 2015·British Journal of Clinical Pharmacology·G MahéS Durand
Feb 8, 2005·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·T A AlamD Baker
Feb 22, 2017·Neuromodulation : Journal of the International Neuromodulation Society·Cristina RussoFelipe Fregni
Jan 22, 2005·The Journal of Physiology·Lacy A HolowatzW Larry Kenney
Jul 18, 2017·Neuromodulation : Journal of the International Neuromodulation Society·Makii MuthalibStéphane Perrey
Jan 19, 2012·Circulation. Cardiovascular Imaging·Guillaume MahéPierre Abraham
Nov 26, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Maylis TartasPierre Abraham
Feb 8, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·P RousseauP Abraham
Jul 11, 2013·The Journal of Pharmacology and Experimental Therapeutics·Sylvain KotzkiJean-Luc Cracowski
Sep 4, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Claire DemiotMarc-Antoine Custaud
Mar 20, 2019·The European Journal of Neuroscience·Zsolt TuriMatthias Mittner
Oct 1, 2005·Journal of Applied Physiology·Brett J WongChristopher T Minson
Jun 10, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·S DurandP Abraham
Oct 22, 2020·Medical Engineering & Physics·Cassandra D Solomons, Vivekanandan Shanmugasundaram

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