Vasodilator dysfunction in aged spontaneously hypertensive rats: changes in NO synthase III and soluble guanylyl cyclase expression, and in superoxide anion production

Cardiovascular Research
J BauersachsR Busse

Abstract

Genetic hypertension is associated with an apparent endothelial dysfunction and impaired endothelium-dependent vasodilatation in response to increased flow and receptor-dependent agonists. However, the link between impaired vasodilatation and nitric oxide (NO) synthase expression is still unclear. In the present study, dilator responses were determined in the aorta and coronary circulation of 16 month old spontaneously hypertensive (SHR) and Wistar Kyoto rats (WKY). Changes in vascular reactivity were compared with alterations in superoxide anion production as well as endothelial NO synthase (NOS III) and soluble guanylyl cyclase expression. In the isolated perfused heart both the bradykinin- and sodium nitroprusside-induced vasodilator responses were attenuated in SHR compared to WKY. Western blot analysis revealed a parallel reduction in NOS III expression in coronary microvascular endothelial cells from SHR. Superoxide anion production in aortae from SHR was markedly elevated over that of aortae from WKY, and was almost completely abolished by pretreatment with superoxide dismutase. Superoxide dismutase induced similar relaxations in phenylephrine-preconstricted aortic rings from both SHR and WKY, but failed to restore the a...Continue Reading

References

Apr 1, 1992·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·R C SharmaQ Jiao
Nov 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·K NakazonoM Inoue
Jun 1, 1990·Hypertension·W Auch-SchwelkP M Vanhoutte
Jul 5, 1990·The New England Journal of Medicine·J A PanzaS E Epstein
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D D ReesS Moncada
Jun 1, 1995·Hypertension·A F Dominiczak, D F Bohr
Jun 1, 1995·Annals of Medicine·R Busse, I Fleming
Jun 1, 1995·Hypertension Research : Official Journal of the Japanese Society of Hypertension·P M Vanhoutte, C M Boulanger
Sep 1, 1996·Circulation Research·R A KellyT W Smith
Jan 1, 1996·British Journal of Pharmacology·A PapapetropoulosJ D Catravas

❮ Previous
Next ❯

Citations

Aug 10, 2007·Current Diabetes Reports·Marcelo L G Correia, William G Haynes
Nov 22, 2001·Current Hypertension Reports·L V d'Uscio, T F Lüscher
Feb 3, 2005·Current Hypertension Reports·Matthias HermannFrank T Ruschitzka
Sep 12, 2000·Current Hypertension Reports·R Busse, I Fleming
Apr 13, 2000·Pharmacology & Therapeutics·A M Shah, P A MacCarthy
Dec 1, 2001·Free Radical Biology & Medicine·M WeberG Kojda
Oct 17, 2002·Nitric Oxide : Biology and Chemistry·Huige LiUlrich Förstermann
May 11, 2012·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Stephan C SchäferLucia Mazzolai
Sep 22, 2009·Cardiovascular Research·Karl Stangl, Verena Stangl
Mar 1, 2008·Clinical and Experimental Pharmacology & Physiology·Xavier LoyerJane-Lise Samuel
May 30, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Mary Pat KunertJulian H Lombard
Sep 7, 2006·The Journal of Clinical Investigation·Johannes-Peter StaschHarald H H W Schmidt
Jan 9, 2010·Vascular Health and Risk Management·Andrew S LevyJames W E Rush
Feb 24, 2007·Pflügers Archiv : European journal of physiology·John J McGuireSarah J Halfyard
Sep 23, 2014·Vascular Cell·Maria Giovanna ScioliAugusto Orlandi
Feb 13, 2016·Genetic Testing and Molecular Biomarkers·Cigdem Yuce KahramanAbdulgani Tatar
Dec 31, 2015·Journal of Translational Medicine·Andreia G F FriquesElisardo C Vasquez
Jan 26, 2010·European Journal of Pharmacology·Katsuhiko NoguchiMatao Sakanashi
Nov 28, 2006·British Journal of Pharmacology·F H ChristensenU Simonsen
Mar 15, 2016·Antioxidants & Redox Signaling·Iraida G Sharina, Emil Martin
Mar 7, 2007·British Journal of Pharmacology·C GerassimouA Papapetropoulos
Mar 31, 2012·International Journal of Experimental Pathology·Azadeh KhaliliShima Fakher
Oct 24, 2013·Nitric Oxide : Biology and Chemistry·Nick D TsihlisMelina R Kibbe
Feb 27, 2004·European Journal of Heart Failure·Andreas SchäferJohann Bauersachs
Sep 18, 2015·Frontiers in Physiology·Marina C Dos Santos MoreiraGustavo R Pedrino
Oct 11, 2002·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Jay L TuttleJoseph L Unthank
Apr 29, 2014·Frontiers in Physiology·Natasha M RogersJeffrey S Isenberg
Jun 29, 1999·The Journal of Surgical Research·T D ReilH A Gelabert
Jun 15, 2000·Blood Pressure·L LindJ Millgård

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.