Vasodilator effect of gaseous sulfur dioxide and regulation of its level by Ach in rat vascular tissues

Inhalation Toxicology
Ziqiang MengFaqi Wang

Abstract

To explore the toxicological and physiological role of gaseous SO(2) on vascular contractility and its level in vascular tissues, a vasodilation study of isolated rat thoracic aortic rings by gaseous SO(2) was carried out. The level of SO(2) in vascular tissue was assayed using a modified high-performance liquid chromatographic method with fluorescence detection (HPLC-FD). The results show that gaseous SO(2) (from 1 microM to 2000 microM) relaxed rat thoracic aortic rings in a dose-dependent manner. The physiological concentrations of SO(2) in thoracic aortic tissues and plasma in rats were 127.76 +/- 31.34 microM and 16.77+/-8.24 microM, respectively; The vasorelaxant effect of gaseous SO(2) at physiological and low concentrations (<450 microM) was endothelium dependent, and at high concentrations (>500 microM) was endothelium independent. The results also show that SO(2) could be endogenously generated in vascular tissues, and mainly in vascular endothelial cells; acetylcholine (Ach) increased the SO(2) level in vascular tissue, and noradrenaline (NE) decreased the SO(2) level. These findings demonstrate that gaseous SO(2) is a vasorelaxant substance, and the vasorelaxant effect of gaseous SO(2) is much stronger than that of ...Continue Reading

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Citations

Dec 25, 2012·Environmental Science and Pollution Research International·Khaleeq AnwarAqeel Javeed
Jan 15, 2014·Life Sciences·Xin-Bao WangHong Cui
Oct 25, 2011·Biochemical and Biophysical Research Communications·Liman LuoJunbao Du
Feb 4, 2016·Oxidative Medicine and Cellular Longevity·Yaqian HuangHongfang Jin
Aug 3, 2010·European Journal of Pharmacology·Junling LiZiqiang Meng
Jan 13, 2009·Nitric Oxide : Biology and Chemistry·Junling Li, Ziqiang Meng
Jul 1, 2015·European Journal of Pharmacology·Xin-Bao WangHong Cui
Apr 1, 2016·ACS Chemical Biology·Jacob J DayMing Xian
Sep 20, 2011·European Journal of Pharmacology·Xin-Bao WangJun-Bao Du
Oct 11, 2016·Oxidative Medicine and Cellular Longevity·Jia LiuJunbao Du
Aug 26, 2017·Chemical Communications : Chem Comm·Wenyi Wang, Binghe Wang
Mar 17, 2020·Biomaterials Science·Ruru LiChun Feng
Apr 22, 2020·Chemical Communications : Chem Comm·Yu ZhangChunsheng Xiao
Dec 7, 2018·Frontiers in Chemistry·Wenyi Wang, Binghe Wang
Jul 18, 2020·Journal of Cardiovascular Pharmacology·Dan ZhouYaqian Huang
Nov 26, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yu ZhangChunsheng Xiao
Apr 13, 2021·Journal of Advanced Research·Lulu ZhangYaqian Huang
Dec 14, 2017·Organic Letters·Kundansingh A PardeshiHarinath Chakrapani

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