Vasodilator effects of desflurane and isoflurane in the feline small intestine

Acta Anaesthesiologica Scandinavica
H SundemanO Winsö

Abstract

The influence of desflurane (DES) and isoflurane (ISO) on the intestinal vasculature was investigated in normoventilated cats (n = 10) during basal chloralose anesthesia (control). We measured heart rate, mean arterial pressure (MAP), and intestinal blood flow (optical drop flowmetry). Intestinal vascular resistance (IVR) was derived. To avoid changes in local vascular tone related to alterations in transmural pressure gradients, intestinal arterial pressure was controlled and kept constant by a variable aortic clamp. Measurements were performed during control and during the administration of DES (3.5% and 7.0% end-tidal) or ISO (0.8% and 1.6% end-tidal). Each animal was exposed to both agents, prior to and after intestinal postganglionic denervation. In the innervated intestine, both DES and ISO dose-dependently decreased IVR. At the high dose, DES (50 +/- 10% decrease in IVR) was a significantly more powerful vasodilator than ISO (37 +/- 12% decrease in IVR). In the denervated intestine, less pronounced vasodilations were produced by both DES and ISO, as compared to the innervated state, and there were, in this situation, no significant differences between agents concerning the magnitude of the vasodilation. As indicated by c...Continue Reading

References

Oct 1, 1992·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·J C HartmanD C Warltier
Aug 1, 1989·Acta Anaesthesiologica Scandinavica·C RanerO Winsö
Jul 1, 1988·Anesthesiology·B M DoorleyJ L Robinson
Sep 1, 1988·Anesthesiology·R B WeiskopfJ G Brown
Jun 1, 1986·British Journal of Anaesthesia·M OstmanS Reiz
Apr 1, 1985·Acta Anaesthesiologica Scandinavica·B A HenrikssonH Sonander
Sep 1, 1972·The American Journal of Physiology·R H Cox

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