Vasodilator effects of estrogen are not diminished by androgen in postmenopausal women

Fertility and Sterility
P M Sarrel, B Wiita

Abstract

To compare the effects of estrogen with estrogen-androgen treatment on vaginal blood flow velocity and fingertip postocclusive hyperemic blood flow response. Prospective, randomized, parallel, double-blind study. Healthy human volunteers in an academic research environment. Postmenopausal women receiving estrogen replacement therapy for at least 12 months and treated with placebo before this investigation. Esterified estrogens or esterified estrogen + methyltestosterone were administered orally; laser Doppler velocimetry was used to determine vaginal and fingertip blood flow responses at baseline and after 4 and 8 weeks of daily drug administration. Fingertip postocclusive area under curve (AUC); vaginal blood flow velocities. The AUC for postocclusive fingertip blood flow and vaginal blood flow increased to a greater extent in the estrogen-androgen group, but changes were not statistically significant between groups. Estrogen-androgen treatment does not diminish the vasodilator effects of estrogen treatment in postmenopausal women.

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Citations

Mar 17, 1999·American Journal of Obstetrics and Gynecology·P M Sarrel
May 15, 2002·Fertility and Sterility·Philip M Sarrel
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