PMID: 6538914Apr 1, 1984Paper

Vasodilator therapy for right ventricular failure

Japanese Circulation Journal
K SakaguchiK Fujita

Abstract

The effects of PGE1 and ISD on right ventricular performance in patients with pulmonary hypertension secondary to chronic lung disease were evaluated, and the following results were obtained. I) Effects of PGE1 on Right Ventricular Failure The effects of PGE1 (intravenous infusion, 0.01 to 0.03 microgram/kg/min) on right ventricular failure were studied in 12 patients with acute exacerbation of chronic respiratory failure. PGE1 resulted in a significant fall in RAP (p less than 0.05), PAMP (from 33.8 +/- 7.6 to 29.3 +/- 5.7 mmHg, p less than 0.005) and TPVR (p less than 0.001), whereas a significant increase in CI (from 3.4 +/- 0.6 to 3.9 +/- 0.6 1/min/m2, p less than 0.001) and SI (p less than 0.005). PaO2 was significantly decreased by PGE1 (p less than 0.02), however PvO2 remained unchanged because of a significant increase of O2-transport (p less than 0.01). PGE1 induced active vasodilation of the pulmonary vascular beds and reduced a right ventricular afterload. We concluded that PGE1 improved the right ventricular failure secondary to chronic lung disease. II) Effects of ISD on Right Ventricular Performance The effects of ISD (intravenous infusion, 0.05 mg/kg/hr) on right ventricular performance were studied at rest and d...Continue Reading

Citations

Sep 1, 1987·The American Review of Respiratory Disease·W A Long, L J Rubin
Jan 1, 1990·Prostaglandins, Leukotrienes, and Essential Fatty Acids·M Moran, P Nicholson
Jan 19, 1999·Critical Care Clinics·J L Zimmerman, N A Hanania

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