PMID: 2114065Jul 1, 1990Paper

Vasodilator therapy in microembolic porcine pulmonary hypertension

Anesthesia and Analgesia
R McLeanR G Pearl

Abstract

The hemodynamic effects of prostaglandin E1, sodium nitroprusside (SNP), nitroglycerin, and hydralazine were studied in a porcine model of elevated pulmonary vascular resistance (PVR) due to glass bead microembolization (60-150-microns diameter). Each animal received all four drugs. Each drug was titrated to produce a 30% reduction in mean systemic arterial pressure. Although all four drugs decreased PVR, distinct differences in the hemodynamic profiles of the four drugs were evident. Prostaglandin E1 produced the largest reduction in mean pulmonary artery pressure (from 41 +/- 1 to 32 +/- 9 mm Hg, mean +/- SEM) and PVR (25 +/- 3 to 18 +/- 2 mm Hg.L-1.min-1), and did not affect the ratio of PVR to systemic vascular resistance (PVR/SVR). Sodium nitroprusside and nitroglycerin produced moderate decreases in PVR (nitroglycerin 21 +/- 2 to 18 +/- 2 mm Hg.L-1.min-1, SNP 22 +/- 2 to 19 +/- 2 mm Hg.L-1.min-1) and in mean pulmonary artery pressure (nitroglycerin 39 +/- 1 to 35 +/- 1; SNP 40 +/- 1 to 36 +/- 2 mm Hg). Both drugs significantly increased the PVR/SVR ratio. Hydralazine was the only drug that significantly increased cardiac output (1.6 +/- 0.2 to 1.9 +/- 0.3 L/min). Hydralazine had no significant effect on mean pulmonary art...Continue Reading

Citations

Mar 1, 1997·The Annals of Thoracic Surgery·E P ChenP Van Trigt
Nov 1, 1995·Critical Care Medicine·I Matot, C F Neely
Oct 24, 2001·American Journal of Respiratory and Critical Care Medicine·J H LeeS D Lee
Jan 1, 1997·Chest·D T Layish, V F Tapson
Aug 1, 1992·Journal of Cardiothoracic and Vascular Anesthesia·M P Hosking, F M Beynen
Jan 30, 2019·Pharmacology Research & Perspectives·Kristofer F Nilsson, Lars E Gustafsson
May 1, 1992·Anaesthesia and Intensive Care·N V RobertsB C Ritchie
Mar 18, 2020·Pulmonary Circulation·Mads Dam LyhneAsger Andersen
Jan 1, 1997·Annales Françaises D'anesthèsie Et De Rèanimation·J StephanazziJ Escarment

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