Vasogenic cerebral edema associated with the disability in activities of daily living in patients with chronic obstructive pulmonary disease

Brain and Behavior
Xiaochuan WangXiaodong Lu

Abstract

The aim of this study was to explore whether patients with chronic obstructive pulmonary disease (COPD) develop vasogenic cerebral edema, and whether this edema contributes to the COPD-related disability. Eighteen stable patients with COPD and 17 matched healthy volunteers were enrolled. Apparent diffusion coefficient (ADC) values were calculated by voxel-based analysis using DTI-Studio software based on diffusion tensor imaging. COPD-related disability was calculated using activities of daily living (ADL) scale. In patients with COPD, ADC increased in the white matter fiber tracts including the bilateral anterior cingulum and posterior corpus callosum and in the white matter fibers connecting the bilateral insular cortices, sub-lobar cortices, and pars triangularis cortices and the left rectus and olfactory gyrus. However, after further controlling for cigarette smoking, the difference in ADC values in the posterior corpus callosum between groups disappeared. Patients with COPD had significantly higher scores in ADL than that in controls. Moreover, ADL scores were positively correlated with the increased regional ADC values. Vasogenic cerebral edema occurs in patients with COPD. Cigarette smoking may be a risk factor for COPD-...Continue Reading

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Software Mentioned

DTI
DCM2NII
MarsBar
SPM8
Studio
FSL Brain Extraction Tool
SPM5
FSL FMRIB

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