Vasohibin-1 suppresses colon cancer

Oncotarget
Shuai LiuGuangyong Peng

Abstract

Vasohibin-1 (VASH1) is an endogenous angiogenesis inhibitor.However, the clinical relevance of VASH1 in colon cancer and its regulations on cancer angiogenesis and cancer cell biological characteristics are still unknown. Here we showed that stromal VASH1 levels were negatively correlated with tumor size, advanced clinical stage and distant metastases in colon cancer patients. Overexpression of VASH1 in colon cancer cells induced apoptosis and senescence, inhibiting cancer cell growth and colony formation in vitro and tumor growth in vivo. In addition, knockdown of VASH1 in cancer cells promoted cell growth, adhesion and migration in vitro, and enhanced tumorigenesis and metastasis in vivo.

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Citations

Oct 24, 2017·The Tohoku Journal of Experimental Medicine·Rikiya SanoMitsuru Shiota
Sep 29, 2020·Frontiers in Cell and Developmental Biology·Lan HuangGuangyong Peng
Sep 9, 2017·Cancer Biology & Therapy·Hua DuYonghong Shi
Oct 19, 2017·Experimental and Therapeutic Medicine·Bo ZhangHailong Hu
Jul 12, 2017·Oncology Letters·Tao ZhangLianjin Zhong
Mar 4, 2021·Journal for Immunotherapy of Cancer·Aiqin GaoGuangyong Peng

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Methods Mentioned

BETA
PCR
transfection
xenograft
FCS
reverse-transcription PCR

Software Mentioned

R
SAS
FlowJo

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