Vasohibin induces prolyl hydroxylase-mediated degradation of hypoxia-inducible factor-1α in human umbilical vein endothelial cells

FEBS Letters
Tomohiro KozakoShinji Soeda

Abstract

Vasohibin is thought to be an important negative feedback regulator of angiogenesis that is selectively induced in endothelial cells by VEGF. Here, we assessed the role of vasohibin on HIF-1α expression under oxidative stress induced by hydrogen peroxide (H₂O₂) in HUVEC. VEGF induced significant cell growth that was associated with an increase in vasohibin expression. Following H₂O₂-pretreatment, VEGF further increased cell growth but this was contrastingly associated with a decrease in vasohibin expression when compared with VEGF alone. Interestingly, vasohibin inhibited cell proliferation through degradation of HIF-1α expression during H₂O₂-pretreatment. Furthermore, vasohibin elevated the expression of prolyl hydroxylase (PHD). These results suggest that vasohibin plays crucial roles as a negative feedback regulator of angiogenesis through HIF-1α degradation via PHD.

References

Jun 6, 1995·Proceedings of the National Academy of Sciences of the United States of America·G L WangG L Semenza
Sep 2, 1999·DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes·R KikunoO Ohara
Oct 13, 2001·Science·R K Bruick, S L McKnight
Feb 2, 2002·Science·David LandoMurray L Whitelaw
Dec 31, 2002·Biochemical Pharmacology·Satoru KoyanagiHiroshi Shimeno
Jun 5, 2003·Nature Medicine·Christopher W Pugh, Peter J Ratcliffe
Sep 18, 2003·Nature Reviews. Cancer·Gregg L Semenza
Jul 13, 2004·The Journal of Biological Chemistry·Rebecca J AppelhoffJonathan M Gleadle
Oct 7, 2004·The Journal of Clinical Investigation·Robert S Kerbel
Oct 7, 2004·The Journal of Clinical Investigation·Kazuhide WatanabeYasufumi Sato
Oct 12, 2004·FEBS Letters·Jason R TuckermanDavid R Mole
Nov 17, 2004·Molecular and Cellular Biochemistry·Masuko Ushio-Fukai, R Wayne Alexander
Sep 6, 2005·Biochemical and Biophysical Research Communications·Christopher J Schofield, Peter J Ratcliffe
May 19, 2006·Biochemical and Biophysical Research Communications·Hiroshi YamashitaYasufumi Sato
May 15, 2007·Journal of Molecular and Cellular Cardiology·Ying DaiMuhammad Ashraf
Jan 12, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Johann KernGerold Untergasser
Apr 15, 2008·Cancer Letters·Masuko Ushio-Fukai, Yoshimasa Nakamura
Feb 18, 2010·Journal of Cellular and Molecular Medicine·Kathryn V Tormos, Navdeep S Chandel
Aug 17, 2010·Cancer Cell·Chunhua LuAnil K Sood
Jan 11, 2011·Journal of Biochemistry·Yasufumi Sato

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Citations

Oct 27, 2012·Journal of Biochemistry·Yasufumi Sato
Feb 8, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Suvro Chatterjee
Sep 9, 2017·Cancer Biology & Therapy·Hua DuYonghong Shi
Aug 25, 2017·BioMed Research International·Katsuyuki TanabeJun Wada
Jul 2, 2020·International Journal of Molecular Sciences·Hiromasa MiyakeJun Wada
Apr 28, 2019·International Journal of Molecular Sciences·Elizabeth Bowler, Sebastian Oltean
Jan 26, 2021·International Journal of Clinical Practice·Yulin LiangYonghua Zhang

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