Vasohibins: new transglutaminase-like cysteine proteases possessing a non-canonical Cys-His-Ser catalytic triad

Bioinformatics
Luis Sanchez-Pulido, Chris P Ponting

Abstract

Vasohibin-1 and Vasohibin-2 regulate angiogenesis, tumour growth and metastasis. Their molecular functions, however, were previously unknown, in large part owing to their perceived lack of homology to proteins of known structure and function. To identify their functional amino acids and domains, their molecular activity and their evolutionary history, we undertook an in-depth analysis of Vasohibin sequences. We find that Vasohibin proteins are previously undetected members of the transglutaminase-like cysteine protease superfamily, and all possess a non-canonical Cys-His-Ser catalytic triad. We further propose a calcium-dependent activation mechanism for Vasohibin proteins. These findings can now be used to design constructs for protein structure determination and to develop enzyme inhibitors as angiogenic regulators to treat metastasis and tumour growth. luis.sanchezpulido@dpag.ox.ac.uk Supplementary data are available at Bioinformatics online.

References

Jul 14, 1995·The Journal of Biological Chemistry·T VernetR Ménard
Dec 5, 1993·Journal of Molecular Biology·A Sali, T L Blundell
Nov 1, 1995·Trends in Biochemical Sciences·L Holm, C Sander
Jun 1, 1996·Current Opinion in Structural Biology·S R Eddy
Aug 19, 1999·Protein Science : a Publication of the Protein Society·K S MakarovaE V Koonin
Feb 11, 2000·Annals of the New York Academy of Sciences·F BernassolaG Melino
Feb 19, 2000·Proceedings of the National Academy of Sciences of the United States of America·T F KagawaE N Baker
Apr 26, 2000·The Journal of Biological Chemistry·M XianP G Wang
Aug 31, 2000·Journal of Molecular Biology·C NotredameJ Heringa
Jun 5, 2003·Nature Reviews. Cancer·Gabriele Bergers, Laura E Benjamin
Dec 19, 2003·Nucleic Acids Research·Antonina AndreevaAlexey G Murzin
Aug 4, 2004·Trends in Biochemical Sciences·Krzysztof GinalskiNick V Grishin
Feb 8, 2005·Acta Crystallographica. Section C, Crystal Structure Communications·Natalia V KuratievaDmitry Yu Naumov
Apr 29, 2005·BMC Bioinformatics·Erik L L Sonnhammer, Volker Hollich
Jun 28, 2005·Nucleic Acids Research·Johannes SödingAndrei N Lupas
Dec 13, 2005·Proceedings of the National Academy of Sciences of the United States of America·Denis VivaresDavid Pignol
Dec 16, 2005·Nature·Napoleone Ferrara, Robert S Kerbel
Dec 31, 2005·Nucleic Acids Research·Cathy H WuBaris Suzek
Jan 10, 2006·Methods in Enzymology·Jean-Marie DupretFernando Rodrigues-Lima
Mar 2, 2006·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·V KukongviriyapanV Bhudhisawasdi
Mar 11, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Takumi ShibuyaYasufumi Sato
Aug 24, 2006·Genome Biology·Victor SolovyevDenis Vorobyev
May 22, 2007·Antioxidants & Redox Signaling·Masuko Ushio-Fukai
Mar 25, 2009·Antioxidants & Redox Signaling·Masuko Ushio-Fukai, Norifumi Urao
Jul 22, 2009·The Journal of Biological Chemistry·Iain D KerrLinda S Brinen
Aug 26, 2010·Journal of Cell Science·Yasuhiro SuzukiYasufumi Sato
Oct 26, 2011·Biochimica Et Biophysica Acta·Vito TurkDušan Turk
Mar 1, 2012·International Review of Cell and Molecular Biology·Maria V Nurminskaya, Alexey M Belkin
Apr 25, 2012·Journal of Tropical Medicine·Kailash C Pandey, Rajnikant Dixit
Jun 19, 2012·Journal of Bacteriology·Debashree ChatterjeeHolger Sondermann
Jul 25, 2012·Molecular Cancer Research : MCR·Yoshifumi TakahashiYasufumi Sato
Oct 27, 2012·Journal of Biochemistry·Yasufumi Sato
Mar 23, 2013·British Journal of Pharmacology·Xiaotong ZhouBaojian Wu
Apr 17, 2013·The Journal of Biological Chemistry·Mariko Honda-OgawaShigetada Kawabata
Sep 26, 2013·PloS One·Soichi ItoYasufumi Sato
Oct 26, 2013·Nucleic Acids Research·Neil D RawlingsAlex Bateman

❮ Previous
Next ❯

Citations

Nov 24, 2016·Protein Science : a Publication of the Protein Society·Tetsuya KadonosonoShinae Kizaka-Kondoh
Sep 9, 2017·Cancer Biology & Therapy·Hua DuYonghong Shi
Jan 10, 2019·Médecine sciences : M/S·Marie-Jo MoutinAnnie Andrieux
Dec 16, 2017·Science·Anna Akhmanova, Helder Maiato
Nov 18, 2017·Science·Joppe NieuwenhuisThijn R Brummelkamp
Jun 27, 2019·Nature Structural & Molecular Biology·Na WangHongda Huang
Jul 5, 2019·Nature Structural & Molecular Biology·Athanassios AdamopoulosAnastassis Perrakis
Jun 27, 2019·Nature Structural & Molecular Biology·Faxiang LiHongtao Yu
Jul 22, 2019·Nature Communications·Chen ZhouZhu Liu
Apr 25, 2020·The Journal of Cell Biology·Luísa T FerreiraHelder Maiato
Jul 5, 2019·Nature Structural & Molecular Biology·Kevin C Slep
Oct 7, 2020·Acta Crystallographica. Section D, Structural Biology·Akihito IkedaTatsuya Nishino
Jan 23, 2021·Current Biology : CB·Takashi HottaRyoma Ohi
Sep 23, 2020·Pharmacology & Therapeutics·Krzysztof RogowskiSiem van der Laan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.