Vasomotor function in rat arteries after ex vivo and intragastric exposure to food-grade titanium dioxide and vegetable carbon particles

Particle and Fibre Toxicology
Ditte Marie JensenP Møller

Abstract

Humans are continuously exposed to particles in the gastrointestinal tract. Exposure may occur directly through ingestion of particles via food or indirectly by removal of inhaled material from the airways by the mucociliary clearance system. We examined the effects of food-grade particle exposure on vasomotor function and systemic oxidative stress in an ex vivo study and intragastrically exposed rats. In an ex vivo study, aorta rings from naïve Sprague-Dawley rats were exposed for 30 min to food-grade TiO2 (E171), benchmark TiO2 (Aeroxide P25), food-grade vegetable carbon (E153) or benchmark carbon black (Printex 90). Subsequently, the vasomotor function was assessed in wire myographs. In an in vivo study, lean Zucker rats were exposed intragastrically once a week for 10 weeks to vehicle, E171 or E153. Doses were comparable to human daily intake. Vasomotor function in the coronary arteries and aorta was assessed using wire myographs. Tetrahydrobiopterin, ascorbate, malondialdehyde and asymmetric dimethylarginine were measured in blood as markers of oxidative stress and vascular function. Direct exposure of E171 to aorta rings ex vivo increased the acetylcholine-induced vasorelaxation and 5-hydroxytryptamine-induced vasocontrac...Continue Reading

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Citations

Jan 4, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Frederikke Emilie Heddagaard, Peter Møller
Jun 22, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Laeticia PerezDominique Lison

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Methods Mentioned

BETA
transmission electron microscopy
light scattering
MDA
dissection
dissecting

Software Mentioned

Nanoparticle Tracking Analysis
GraphPad Prism
ImageJ

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