PMID: 3769410Nov 1, 1986Paper

Vasopressin and catecholamine secretion during apomorphine-induced nausea mediate acute changes in haemostatic function in man

Clinical Science
P J GrantC R Prentice

Abstract

Seven male volunteers were given apomorphine (14-20 micrograms/kg) subcutaneously on a total of ten occasions. Nausea was experienced on six occasions and on four occasions there was no effect. Venous samples were taken before injection, at peak nausea and 20 min later for assay of factor VIII coagulant activity (FVIIIC), von Willebrand factor antigen (vWFAg), the ristocetin cofactor (FVIIIRiCof), euglobulin clot lysis time (ECLT), fibrinopeptide A (FPA), FPA generation time, activated partial thromboplastin time (APTT), vasopressin (aVP) and adrenaline. During nausea plasma aVP concentrations rose from median values of 0.4 pg/ml (at time 0) to 76 pg/ml at peak nausea and fell to 32 pg/ml 20 min later. Adrenaline rose from 0.36 to 0.91 nmol/l (P less than 0.05) before falling to 0.55 nmol/l. During nausea, FVIIIC rose from 100% to 143% (P less than 0.05) and to 214% (P less than 0.05) 20 min later. FVIIIRiCof and vWFAg showed similar changes. Plasminogen activator activity (10(6)/ECLT2) rose from 23 units at time 0 to 592 units during nausea and 1135 units (P less than 0.05) after 20 min. The APTT fell from 49 s to 44 s during the study, plasma FPA levels and the FPA generation time both remained unchanged. On the four occasion...Continue Reading

Citations

Mar 25, 2006·Autonomic Neuroscience : Basic & Clinical·Paul L R Andrews, Charles C Horn
Jul 27, 2001·Fundamental & Clinical Pharmacology·L GrélotC Serradeil-Le Gal
Mar 1, 1988·Cephalalgia : an International Journal of Headache·R C PeatfieldP J Grant
Dec 28, 2002·Acta Biologica Hungarica·R M Stern

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