Vasopressin and nitric oxide synthesis after three days of water or food deprivation

Acta Biologica Hungarica
B MornaguiN Gharbi

Abstract

Nitric oxide has been suggested to be involved in the regulation of fluid and nutrient homeostasis. In the present investigation, vasopressin and nitric oxide metabolite (nitrite and nitrate) levels were determined in plasma of male Wistar rats submitted to water or food deprivation for three days. Hematocrit and plasma sodium showed marked increase in dehydrated and starved rats. Potassium levels and plasma volume decreased in both treated groups. Plasma osmolality and vasopressin levels were significantly elevated in water deprived (362.8 +/- 7.1 mOsm/kg H2O, 17.3 +/- 2.7 pg/ml, respectively, p < 0.001) rats, but not in food deprived (339.9 +/- 5.0, 1.34 +/- 0.28) rats, compared to the controls (326.1 +/- 4.1, 1.47 +/- 0.32). The alterations observed in plasma vasopressin levels were related to plasma osmolality rather than plasma volume. Plasma levels of nitrite and nitrate were markedly increased in both water and food deprived rats (respectively, 2.19 +/- 0.29 mg/l and 2.22 +/- 0.17 mg/l versus 1.33 +/- 0.19 mg/l, both p < 0.01). There was a significant negative correlation between plasma nitrite and nitrate concentration and plasma volume. These results suggest that both dehydration and starvation increase plasma nitric o...Continue Reading

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Citations

Mar 16, 2011·European Journal of Nutrition·Andrea Lorena FelletAna María Balaszczuk
Aug 10, 2010·Journal of Physiology and Biochemistry·Bessem MornaguiNajoua Gharbi
May 1, 2010·International Journal of Diabetes in Developing Countries·Daniel Maciel CrespilhoEliete Luciano
Feb 10, 2009·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·J A C A LemeE Luciano
Sep 14, 2018·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Bethany L WilliamsJon P Costanzo
Jun 28, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Pieter de LangeAntonia Lanni
May 27, 2011·American Journal of Botany·Brad R RuhfelCharles C Davis
Sep 23, 2020·Photochemistry and Photobiology·Alessia Baseggio ConradoSally Helen Ibbotson

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