PMID: 3756483Aug 20, 1986Paper

Vasopressin binds to microvessels from rat hippocampus

Brain Research
R KretzschmarA Ermisch

Abstract

Recent evidence suggests that vasopressin may influence the permeability of the endothelium of brain capillaries. We measured the binding of [125I]arginine-8-vasopressin ([125I]AVP) to microvessels isolated from different regions of the rat brain. The study revealed saturable and specific binding of [125I]AVP to microvessels isolated from hippocampus. Scatchard analysis confirmed a single class of high affinity sites with an equilibrium dissociation constant, Kd, of 3.2 nM and an apparent maximal binding capacity of 205 fmol/mg protein. No binding was observed to microvessels from neocortex and striatum.

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Citations

Jun 27, 1990·Biochimica Et Biophysica Acta·B V ZlokovicH Davson
Dec 19, 1988·Neuroscience Letters·G A RosenbergW T Kyner
Oct 11, 1992·Journal of Neurochemistry·P BrustA Ermisch
Jan 1, 1990·Annals of the New York Academy of Sciences·T SmockP McMechen
Sep 1, 1992·Journal of Neurosurgery·Y SuzukiK Sugita
Dec 30, 2011·Brain Structure & Function·Sylvia Van DorpeBart De Spiegeleer
Dec 1, 1992·Stroke; a Journal of Cerebral Circulation·G A RosenbergW T Kyner
Apr 1, 2005·American Journal of Physiology. Cell Physiology·Martha E O'DonnellDenise M Johnson
Oct 11, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Kasper LykkeNanna MacAulay
Dec 24, 2002·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Eric HollanderSerge Mosovich
Jan 1, 1989·Journal of Endocrinological Investigation·G Ramieri, G C Panzica

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