Vasopressin, Central Autonomic Control and Blood Pressure Regulation

Current Hypertension Reports
Maja LozićNina Japundžić-Žigon

Abstract

We present recent advances in understanding of the role of vasopressin as a neurotransmitter in autonomic nervous system control of the circulation, emphasizing hypothalamic mechanisms in the paraventricular nucleus (PVN) involved in controlling sympathetic outflow toward the cardiovascular system. Suggest that somato-dendritically released vasopressin modulates the activity of magnocellular neurons in the PVN and SON, their discharge pattern and systemic release. Advances have been made in uncovering autocrine and paracrine mechanisms controlling presympathetic neuron activity, involving intranuclear receptors, co-released neuroactive substances and glia. It is now obvious that intranuclear release of vasopressin and the co-release of neuroactive substances in the PVN, as well as the level of expression of vasopressin receptors, modulate sympathetic outflow to the cardiovascular system and determine vulnerability to stress. Further research involving patho-physiological models is needed to validate these targets and foster the development of more efficient treatment.

References

Aug 11, 1989·European Journal of Pharmacology·R Gerstberger, F Fahrenholz
Jan 1, 1982·Annals of the New York Academy of Sciences·K H BerecekM J Brody
Oct 1, 1995·Differentiation; Research in Biological Diversity·Y KatoM Kobayashi
Jan 1, 1996·Critical Reviews in Neurobiology·C Barberis, E Tribollet
Aug 1, 1996·Journal of Hypertension·J Chalmers, A Zanchetti
Jul 15, 1999·The Journal of Comparative Neurology·M Hallbeck, A Blomqvist
May 22, 2001·Journal of Neurochemistry·A ReauxC Llorens-Cortès
Jun 28, 2001·Physiological Reviews·J P BurbachH Gainer
May 3, 2002·Clinical and Experimental Pharmacology & Physiology·R A L DampneyT Tagawa
Jul 13, 2002·Cardiac Electrophysiology Review·Federico Lombardi
Oct 26, 2002·Molecular Psychiatry·S R WersingerW S Young
Oct 30, 2004·Stress : the International Journal on the Biology of Stress·Simona VolpiGreti Aguilera
Dec 8, 2004·Regulatory Peptides·Shuntaro KagiyamaMitsuo Iida
Jan 18, 2005·Pharmacology, Biochemistry, and Behavior·Robert J BlanchardD Caroline Blanchard
Jan 24, 2006·Nature Reviews. Neuroscience·Mike Ludwig, Gareth Leng
May 10, 2006·Proceedings of the National Academy of Sciences of the United States of America·Taka-aki KoshimizuGozoh Tsujimoto
Jun 9, 2006·Nature Reviews. Neuroscience·Patrice G Guyenet
Jun 14, 2008·Journal of Hypertension·Krzysztof Narkiewicz, Guido Grassi
Jul 29, 2008·Progress in Brain Research·Colin H BrownMike Ludwig
Mar 20, 2010·Hormones and Behavior·Heather K CaldwellW Scott Young
Nov 1, 2011·Clinical and Experimental Nephrology·Yoko FujiwaraTaka-Aki Koshimizu
Apr 18, 2012·European Heart Journal·Gianfranco Parati, Murray Esler
Jun 15, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Evgeniy S PotapenkoJavier E Stern
Aug 21, 2012·Current Hypertension Reports·Gianfranco ParatiGrzegorz Bilo
Oct 18, 2012·Physiological Reviews·Taka-aki KoshimizuAkito Tanoue
Jan 30, 2013·Hypertension·Gerald F DiBona
Mar 16, 2013·British Journal of Pharmacology·Sanja Milutinović-SmiljanićNina Japundžić-Žigon
Sep 3, 2013·Current Neuropharmacology·Nina Japundžić-Žigon
Sep 27, 2013·International Journal of Health Services : Planning, Administration, Evaluation·Alison Rosamund Katz
May 2, 2014·Proceedings of the National Academy of Sciences of the United States of America·Susanne M BrunnerBarbara Kofler

❮ Previous
Next ❯

Citations

Aug 30, 2018·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Anne M FinkMichael W Calik
Feb 15, 2020·American Journal of Physiology. Heart and Circulatory Physiology·E Szczepanska-SadowskaA Wsol
May 29, 2020·Pflügers Archiv : European journal of physiology·Atsunori YamamotoHideyuki Yamawaki
Mar 30, 2019·Molecular Neurobiology·Bérenger LargeauStephan Ehrmann
May 24, 2019·Annals of the New York Academy of Sciences·Gareth LengStewart Maclean
Sep 10, 2020·Frontiers in Neuroanatomy·Si-Yuan SongLi-Cai Zhang
Jan 9, 2019·Frontiers in Neuroscience·Elba Campos-LiraJerome D Swinny
Oct 25, 2020·Acta Neuropathologica·Brittney L BlevinsPeter T Nelson
Dec 3, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Dragana KomnenovNoreen F Rossi
Jan 22, 2021·Journal of Perioperative Practice·Christopher Wood
Jan 5, 2021·Current Opinion in Nephrology and Hypertension·Jing LiElaine M Richards
Oct 20, 2020·Frontiers in Neuroscience·Erin C McKay, Scott E Counts
Oct 15, 2020·Current Topics in Medicinal Chemistry·Yana LernerNir Qvit
Jul 24, 2021·Journal of Neuroendocrinology·Audrys G PaužaMichael P Greenwood
Jul 9, 2021·Journal of Neuroendocrinology·Quentin J Pittman
Aug 27, 2021·Frontiers in Neuroendocrinology·Haiyan ZhengSun Wook Hwang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.