Vasopressin effects on the coronary circulation after a short ischemia in anesthetized goats: role of nitric oxide and prostanoids

European Journal of Pharmacology
Godofredo DiéguezLuis Monge

Abstract

To examine the coronary effects of arginine-vasopressin during reperfusion after a short ischemia, left circumflex coronary artery flow was electromagnetically measured, and 15 min total occlusion of this artery followed by reperfusion was induced in anesthetized goats (five nontreated, five treated with the inhibitor of nitric oxide synthesis Nomega-nitro-L-arginine methyl ester (L-NAME) and five treated with the inhibitor of cyclooxygenase meclofenamate). The vasoactive drugs and L-NAME were intracoronarily injected, and meclofenamate by i.v. route. At 60 min of reperfusion, coronary vascular conductance was not changed significantly in nontreated and was decreased by 35% (P<0.01) in L-NAME-treated and by 30% (P<0.01) in meclofenamate-treated animals. During reperfusion, the coronary vasodilatation with acetylcholine (3-100 ng) and sodium nitroprusside (1-10 microg) was not altered in nontreated animals, and the vasodilatation with acetylcholine but not with sodium nitroprusside was partially decreased in L-NAME--but not in meclofenamate-treated animals. The vasoconstriction in response to arginine-vasopressin (0.03-0.3 microg) was increased during reperfusion in nontreated, was not changed in L-NAME-treated and was decreased...Continue Reading

References

Mar 1, 1989·Microvascular Research·W W Lautt
Oct 1, 1995·Cardiovascular Research·N MaulikD K Das
Aug 1, 1996·British Journal of Pharmacology·A L García-VillalónG Diéguez
Feb 24, 2001·The Annals of Thoracic Surgery·U LockowandtA Franco-Cereceda
Jul 25, 2003·European Journal of Pharmacology·María Angeles MartínezGodofredo Diéguez
Nov 26, 2003·European Journal of Pharmacology·Nuria FernándezGodofredo Diéguez

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Citations

Nov 26, 2008·Cardiovascular Research·Angel Luis García-VillalónGodofredo Diéguez
Aug 12, 2009·Critical Care : the Official Journal of the Critical Care Forum·Pierre Asfar, Peter Radermacher
Jul 1, 2015·International Journal of Endocrinology·Carlo Dal LinElena Osto

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