Vasopressin for hemorrhagic shock management: revisiting the potential value in civilian and combat casualty care

The Journal of Trauma
Wolfgang G VoelckelHelmut Trimmel

Abstract

The evolution of trauma care is driven by a synergistic relationship between civilian and military medical systems. Although the characteristics of civilian injuries differ from those encountered on the battlefield, the pathophysiologic process of dying is the same and dominated by exsanguination and central nervous trauma. As such, therapies that interfere with the physiologic ability to compensate hemorrhage may play a key role to buy time until hemostatic surgery can be initiated. From a variety of remedies with the potential to prolong the compensation phase or to reverse the decompensation phase of shock, arginine vasopressin (AVP) is one of the most promising and best-evaluated drugs. Animal studies and various case report series provide some evidence that AVP may improve blood pressure even when conventional therapies fail, thus preventing hypovolemic cardiac arrest and enabling resuscitation from fatal hemorrhage. On the basis of this civilian experience, it seems reasonable to consider AVP for hypotensive resuscitation in the austere, resource-constrained battlefield environment. However, the significance of AVP as a rescue medication for life-threatening hemorrhage has yet to be proven.

References

Jul 24, 2001·Langenbeck's Archives of Surgery·C Hierholzer, T R Billiar
Oct 24, 2001·Anaesthesia and Intensive Care·P Forrest
May 3, 2002·Clinical and Experimental Pharmacology & Physiology·Joseph E Brayden
Jan 9, 2004·The New England Journal of Medicine·Volker WenzelUNKNOWN European Resuscitation Council Vasopressor during Cardiopulmonary Resuscitation Study Group
Oct 5, 2006·The Journal of Veterinary Medical Science·Jong-Hyun YooHee-Myung Park
Nov 30, 2006·Critical Care : the Official Journal of the Critical Care Forum·Martin W Dünser, Walter R Hasibeder
Jul 13, 2007·The Journal of Trauma·John G McManusJohn B Holcomb
Jul 13, 2007·The Journal of Trauma·Stephen M Cohn
Jul 31, 2007·Critical Care : the Official Journal of the Critical Care Forum·Karl H StadlbauerVolker Wenzel
Aug 7, 2007·The Journal of Veterinary Medical Science·Jong-Hyun YooHee-Myung Park
Dec 20, 2007·Shock·Isabella WestermannWolfgang G Voelckel
Dec 25, 2007·Military Medicine·Frank K ButlerJames Bagian
Jan 12, 2008·The Journal of Trauma·Jason L SperryRam Nirula
Apr 30, 2008·Current Opinion in Anaesthesiology·Martin W Dünser, Martin Westphal

❮ Previous
Next ❯

Citations

Sep 20, 2012·Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine·Roger F Shere-WolfeThomas E Grissom
Dec 19, 2012·Journal of Emergencies, Trauma, and Shock·Fabrizio Giuseppe Bonanno
Mar 5, 2013·Injury·Naeem GoussousMartin D Zielinski
Aug 2, 2012·The Surgical Clinics of North America·Jeffrey D Kerby, Marianne V Cusick
Aug 3, 2012·Revista española de anestesiología y reanimación·R Navarro SuayJ M Jiménez Vizuete
Apr 7, 2012·The Journal of Surgical Research·Tanya Anand, Ruby Skinner
Nov 22, 2011·The American Journal of Emergency Medicine·Basak BayramSule Kalkan
Jul 2, 2011·Current Problems in Surgery·Hasan B Alam, George C Velmahos
Sep 26, 2014·BioMed Research International·Andrea Pasquale CossuGabriele Finco
Nov 5, 2014·PloS One·Vesna Borovnik-LesjakRaúl J Gazmuri
Nov 5, 2011·Journal of the Royal Army Medical Corps·A KehoeC Smith
May 21, 2016·American Journal of Physiology. Heart and Circulatory Physiology·P H RatzR W Barbee

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.