Vasopressin gene expression is attenuated in the fetal Brattleboro rat

FEBS Letters
H H Van TolJ P Burbach

Abstract

Due to a genetic defect the homozygous Brattleboro rat is unable to synthesize vasopressin gene products but still transcribes a mutant vasopressin mRNA from the gene. To study the influence of vasopressin gene products on the development of vasopressin gene expression, vasopressin mRNA levels of the supraoptic and paraventricular nucleus were measured at fetal day 20, postnatal day 1, 15 and 30 in the Wistar rat and in the heterozygous and homozygous Brattleboro rat by Northern blot analysis and in situ hybridization. In the homozygous Brattleboro rat of fetal day 20 and postnatal day 1, no or minute amounts of vasopressin mRNA were detectable but vasopressin mRNA was readily detectable at postnatal day 15 and 30. The Wistar rat and heterozygous Brattleboro rat had abundant vasopressin mRNA at fetal day 20 with increasing amounts towards postnatal day 30. The results indicate that vasopressin gene expression in the development of the homozygous Brattleboro rat is attenuated, possibly due to the absence of vasopressin gene products.

References

Nov 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·G K McMaster, G G Carmichael
Aug 11, 1986·FEBS Letters·H H Van TolJ P Burbach
Dec 1, 1986·Brain : a Journal of Neurology·F G van der Meché, J van Gijn
Aug 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·G R UhlJ F Habener
Sep 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·J A MajzoubJ F Habener
Jan 1, 1982·Annals of the New York Academy of Sciences·J F Morris
Jan 1, 1982·Annals of the New York Academy of Sciences·H DlouháJ Zicha
Jan 1, 1982·Annals of the New York Academy of Sciences·G J BoerD F Swaab
Aug 11, 1980·Brain Research·C SindingP G Schmid
Feb 1, 1964·The American Journal of Physiology·H VALTIN, H A SCHROEDER

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Citations

Dec 1, 1987·Cellular and Molecular Neurobiology·W S Young, R T Zoeller
Aug 11, 1986·FEBS Letters·H H Van TolJ P Burbach
Nov 18, 1994·Brain Research. Developmental Brain Research·M T PanayotacopoulouD F Swaab
Oct 1, 1992·Journal of Neuroendocrinology·W S Young
Jan 31, 1989·Biochemical and Biophysical Research Communications·S FehrD Richter
May 29, 1987·Biochemical and Biophysical Research Communications·J P BurbachR Ivell
Jan 1, 1988·Clinical and Experimental Hypertension. Part A, Theory and Practice·J T McCabeD Ganten
Jun 28, 2001·Physiological Reviews·J P BurbachH Gainer

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