Vasopressin impairs or enhances retention of learned submissive behavior in mice depending on the time of application

Behavioural Brain Research
B SiegfriedP G Waser

Abstract

The effects of vasopressin on learning and memory were investigated in a paradigm using adaptive capabilities of interacting male mice. Test animals of the DBA/2 strain which were not submissive in a confrontation with a non-aggressive subordinate C57BL/6 mouse on day 1 (baseline), were defeated on day 2 (learning) by an aggressive dominant C57 mouse, and showed learned submissive behavior upon mere contact with a non-aggressive C57 mouse on day 3 (retest). Pretrial injections of lysine-vasopressin (0.01, 0.1 or 1.0 I.U., s.c.) 20 min before defeat on day 2 resulted in less submissive behavior on day 3 compared to controls, with 0.1 I.U. (equal to 370 ng) being the most effective dose. Post-trial injections of vasopressin (0.1 I.U.) immediately after defeat on day 2 significantly improved retention on day 3. Preretention injections of vasopressin (0.1 I.U.) 20 min before testing on day 3 significantly increased learned submissive behavior. The amnesic effect observed after pretrial injections of vasopressin was neither due to state dependency nor to an acquisition deficit, nor to antinociception. It is concluded that processing of the stressful experience of defeat is differently influenced by vasopressin given before or after ...Continue Reading

References

Jan 7, 1978·Lancet·J J LegrosP Berchier
Dec 1, 1976·Hormones and Behavior·P E Gold, R van Buskirk
May 1, 1977·Physiology & Behavior·A I Leshner, K E Roche
Jul 1, 1979·European Journal of Pharmacology·I KrejcíK Jost
Aug 1, 1978·Pharmacology, Biochemistry, and Behavior·W D Pfeifer, H B Bookin
Nov 1, 1977·Endocrinology·R E WeitzmanR Guillemin
Jan 1, 1974·Physiology & Behavior·P GarrudD de Wied
Sep 1, 1972·Hormones and Behavior·B BohusD de Wied
Jun 1, 1974·Journal of Comparative and Physiological Psychology·A R King, D de Wied
Jan 1, 1982·Neurobiology of Aging·R T BartusB Beer
Dec 5, 1980·European Journal of Pharmacology·W KnepelG Hertting
Jan 1, 1983·Pharmacology & Therapeutics·T B van Wimersma GreidanusD de Wied
Oct 1, 1983·Neuroendocrinology·H StegnerD A Fisher
Jan 22, 1982·Neuroscience Letters·A SahgalJ A Edwardson
Mar 1, 1982·Pharmacology, Biochemistry, and Behavior·M E Judge, D Quartermain
Nov 1, 1982·Behavioral and Neural Biology·J J HaganD de Wied
Mar 19, 1982·Science·K A MiczekL Shuster
Jan 1, 1980·Peptides·O Buresová, J Skopková
Jan 1, 1980·Neurobiology of Aging·R L CooperW G Thompson
Jan 1, 1980·Neuroendocrinology·G HostetterG P Kozlowski
Feb 6, 1981·Science·H WeingartnerF K Goodwin

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Citations

Jan 1, 1985·Psychopharmacology·H R FrischknechtP G Waser
Sep 17, 2004·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Cliff H SummersNeil Greenberg
Jul 1, 1991·Physiology & Behavior·J Alliot, T Alexinsky
Jan 1, 1993·Behavioral and Neural Biology·D MetzgerB Soumireu-Mourat
Dec 14, 1990·Behavioural Brain Research·B Alescio-Lautier, B Soumireu-Mourat
May 1, 1992·Neuroscience Research·S Shiosaka
Sep 1, 1984·Behavioral and Neural Biology·B SiegfriedP G Waser
Jul 1, 1988·Behavioral and Neural Biology·S Puglisi-Allegra, S Cabib
Jan 12, 2005·Physiology & Behavior·UnJa L Hayes, Kathleen C Chambers
Dec 1, 2017·Frontiers in Endocrinology·Joseph I TerranovaH Elliott Albers

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