Vasopressin-induced calcium signaling in cultured cortical neurons

Brain Research
M C Son, R D Brinton

Abstract

Earlier autoradiographic studies from our laboratory detected vasopressin recognition sites in the mammalian cerebral cortex [R.E. Brinton, K.W. Gee, J.K. Wamsley, T.P. Davis, H.I. Yamamura, Regional distribution of putative vasopressin receptors in rat brain and pituitary by quantitative autoradiography, Proc. Natl. Acad. Sci. U. S.A., 81 (1984) 7248-7252; C. Chen, R.D. Brinton, T.J. Shors, R.F. Thompson, Vasopressin induction of long-lasting potentiation of synaptic transmission in the dentate gyrus, Hippocampus, 3 (1993) 193-204]. More recently, we have detected mRNA for the V1a vasopressin receptors (V1aRs) in cultured cortical neurons [R.S. Yamazaki, Q. Chen, S.S. Schreiber, R.D. Brinton, V1a Vasopressin receptor mRNA expression in cultured neurons, astroglia, and oligodendroglia of rat cerebral cortex, Mol. Brain Res., 45 (1996) 138-140]. To determine whether these recognition sites are functional receptors, we have pursued the signal transduction mechanism associated with the V1a vasopressin receptor in enriched cultures of cortical neurons. Results of these studies demonstrate that exposure of cortical neurons to the selective V1 vasopressin receptor agonist, [Phe2,Orn8]-vasotocin, (V1 agonist) induced a significant acc...Continue Reading

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Citations

Jun 29, 2002·Brain Research·Lixia Zhao, Roberta Diaz Brinton
Oct 18, 2000·European Journal of Pharmacology·R D BrintonE A Brownson
Feb 19, 2008·European Journal of Pharmacology·Mario Raggenbass
Jun 17, 2004·American Journal of Physiology. Endocrinology and Metabolism·Yoshitaka YamaguchiNobuo Suzuki
Jul 9, 2017·Cardiovascular Toxicology·Melissa Chudow, Kevin Ferguson

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