Vasopressin-induced changes in splanchnic blood flow and hepatic and portal venous pressures in liver resection

Acta Anaesthesiologica Scandinavica
L Sand BownS Lundin

Abstract

To minimize blood loss during hepatic surgery, various methods are used to reduce pressure and flow within the hepato-splanchnic circulation. In this study, the effect of low- to moderate doses of vasopressin, a potent splanchnic vasoconstrictor, on changes in portal and hepatic venous pressures and splanchnic and hepato-splanchnic blood flows were assessed in elective liver resection surgery. Twelve patients were studied. Cardiac output (CO), stroke volume (SV), mean arterial (MAP), central venous (CVP), portal venous (PVP) and hepatic venous pressures (HVP) were measured, intraoperatively, at baseline and during vasopressin infusion at two infusion rates (2.4 and 4.8 U/h). From arterial and venous blood gases, the portal (splanchnic) and hepato-splanchnic blood flow changes were calculated, using Fick's equation. CO, SV, MAP and CVP increased slightly, but significantly, while systemic vascular resistance and heart rate remained unchanged at the highest infusion rate of vasopressin. PVP was not affected by vasopressin, while HVP increased slightly. Vasopressin infusion at 2.4 and 4.8 U/h reduced portal blood flow (-26% and -37%, respectively) and to a lesser extent hepato-splanchnic blood flow (-9% and -14%, respectively). Th...Continue Reading

References

Apr 1, 1986·The Journal of Clinical Investigation·T J EbertM Skelton
Jun 1, 1982·The Journal of Endocrinology·T JanákyJ L Morgat
Nov 1, 1996·The British Journal of Surgery·M ReesS Bygrave
Mar 21, 1998·The British Journal of Surgery·M JohnsonA V Wu
Aug 6, 1999·British Journal of Anaesthesia·M Tanaka, T Nishikawa
Mar 8, 2006·World Journal of Gastroenterology : WJG·Wei-Dong WangXiao-Yu Yin
Apr 26, 2007·Annals of Surgery·Takuya HashimotoMasatoshi Makuuchi
Sep 7, 2007·Langenbeck's Archives of Surgery·Zahir F SoonawallaPeter J Friend
Nov 1, 2008·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Gebhard WagenerDonald Landry
Dec 4, 2010·Journal of Cardiothoracic and Vascular Anesthesia·Gebhard WagenerDonald W Landry
Sep 26, 2014·BioMed Research International·Andrea Pasquale CossuGabriele Finco
Jan 27, 2015·Journal of Cardiothoracic and Vascular Anesthesia·Ahmed MukhtarMahmoud El Meteini

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Citations

Mar 27, 2018·Acta Anaesthesiologica Scandinavica·E WisénS-E Ricksten
Apr 20, 2018·Acta Anaesthesiologica Scandinavica·H Haugaa, L M Ytrebø
Aug 23, 2018·Journal of Intensive Care Medicine·Kristen A SeversonWilliam J Gordon
Sep 24, 2020·BMC Anesthesiology·Jurgen van LimmenLuc De Baerdemaeker
Jul 3, 2020·Minerva anestesiologica·Javier Ripollés-MelchorManuel I Monge García
Jan 5, 2021·Current Opinion in Critical Care·Annika Reintam BlaserYaseen M Arabi
Apr 29, 2021·Anesthesia and Analgesia·Justin E RichardsTobias Gauss

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