Vasopressin mechanism-mediated pressor responses caused by central angiotensin II in the ovine fetus

Pediatric Research
Lijun ShiZhice Xu

Abstract

AVP not only influences renal water excretion but also has profound cardiovascular effects in adults. Our recent studies have demonstrated that central angiotensin induced fetal pressor responses accompanied with AVP release. However, little is known of hormonal mechanisms in angiotensin-mediated fetal blood pressure (BP) changes. The present study determined AVP mechanisms in central angiotensin-mediated fetal pressor responses. The V1-receptor antagonist or V2-receptor antagonist was infused intravenously into the ovine fetus at 90% gestation. Angiotensin II (Ang II; 1.5 microg/kg) was then injected intracerebroventricularly into the chronically instrumented fetus. Ang II produced a significant increase in fetal systolic, diastolic, and mean arterial pressure adjusted to amniotic pressure (A-MAP). The enhanced fetal A-MAP was associated with intense c-fos expression in the central putative cardiovascular area: the paraventricular nuclei (PVN). Double labeling demonstrated that a number of the AVP-containing neurons in the PVN were expressing c-fos in response to central Ang II. Consistent with the activation of AVP neurons in the PVN, fetal plasma AVP was markedly enhanced. Fetal i.v. V1-receptor antagonist or V2-receptor ant...Continue Reading

References

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Citations

Apr 8, 2010·American Journal of Physiology. Endocrinology and Metabolism·Lijun ShiZhice Xu
Apr 25, 2012·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Juan GaoLie Gao
May 9, 2006·Critical Care : the Official Journal of the Critical Care Forum·Sascha MeyerLudwig Gortner
Apr 12, 2007·Pediatric Research·Sithembiso C VelaphiCharles R Rosenfeld
Apr 15, 2008·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Caiping MaoZhice Xu
Dec 4, 2012·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Li YuLie Gao
Sep 1, 2012·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Marcelo Cardoso de LimaJosé Antonio Rocha Gontijo

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