Vasopressin modulation of medullary blood flow and pressure-natriuresis-diuresis in the decerebrated rat

The American Journal of Physiology
K G FranchiniA W Cowley

Abstract

Studies in our laboratory and others have demonstrated that arginine vasopressin (AVP) exerts potent vasoconstrictor actions on the vessels supplying the renal medulla. The physiological importance of these vascular effects of AVP has been difficult to assess because of high endogenous levels of AVP in anesthetized, surgically prepared animals. We have developed a decerebrated, hypophysectomized, renal-denervated rat model that enables us to study the effects of low levels of AVP on the pressure-diuresis, relationship under acute conditions. These rats maintain normal mean arterial pressure (MAP) and plasma AVP (2.5 pg/ml). Cortical and medullary blood flow (CBF and MBF, respectively) were measured by laser-Doppler flowmetry and total renal blood flow (RBF) by transit time flowmetry. Renal interstitial fluid pressure (RIFP) and urinary sodium excretion (UNaV) responses were determined during controlled increases of MAP produced by aortic occlusion below the renal arteries. From a baseline of 97 +/- 2 mmHg, 30% increases in MAP resulted in a 63% increase in MBF, 35% increase in RIFP, and sixfold increase in UNaV, whereas CBF and RBF remained unchanged. Infusion of AVP (0.50 ng.kg-1.min-1, which increased plasma AVP from normal c...Continue Reading

Citations

Feb 27, 2015·American Journal of Physiology. Renal Physiology·Anita T Layton
Feb 21, 2014·American Journal of Physiology. Renal Physiology·Robert Moss, Anita T Layton
Jun 10, 2016·Mathematical Medicine and Biology : a Journal of the IMA·Ioannis SgouralisAnita T Layton
Nov 18, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·R Y InoueK G Franchini
Jan 17, 2003·American Journal of Physiology. Renal Physiology·Thomas L PalloneKristie Rhinehart
Oct 11, 2013·American Journal of Physiology. Renal Physiology·Robert Moss, S Randall Thomas
Apr 3, 2015·Physiological Reviews·Mattias CarlströmWilliam J Arendshorst
Aug 4, 2006·American Journal of Physiology. Renal Physiology·Ningjun LiPin-Lan Li

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