Vasopressin serum levels in patients with severe brain lesions and in brain-dead patients

Arquivos de neuro-psiquiatria
Eliane de Araújo CintraRosmari A R A Oliveira

Abstract

Patients with severe brain lesions (SBL) and brain-dead patients (BD) frequently present with vasopressin (AVP) secretion disorders. To evaluate AVP serum levels in SBL and BD patients. Prospective, open label, observational trial. A general teaching hospital. Three groups of adult subjects (age> 18y) of both sexes were included in this study: control group: 29 healthy volunteers; SBL group: 17 patients with Glasgow Coma Scale (GCS)< 8; and BD group: 11 brain-dead patients. Samples of venous blood were collected in the morning at rest from healthy volunteers and at 8 hourly intervals over a period of 24h from SBL and BD patients for AVP determinations. Concomitantly, some clinical and laboratorial variables were also recorded. AVP serum levels (pg/ml) were [mean (SD); median]: control [2.2(1.1); 2.0]; SBL [5.7(6.3); 2.9]; and BD [2.6(1.0); 2.8]. AVP serum levels varied greatly in SBL patients, but without statistically significant difference in relation to the other groups (p=0.06). Hypotension (p=0.02), hypernatremia (p=0.0001), serum hyperosmolarity (p=0.0001) and urinary hypoosmolarity (p=0.003) were outstanding in BD patients when compared with SBL. The AVP serum levels did not demonstrate significant statistical difference...Continue Reading

References

Nov 1, 1992·Transplantation·H J GrammK Voigt
Jul 1, 1990·Critical Care Medicine·D J PownerR L Madden
May 15, 1989·Annals of Internal Medicine·B Soifer, A W Gelb
Feb 1, 1987·Kidney International·F MorelD Chabardès
Oct 1, 1988·Physiological Reviews·L Share
Jun 1, 1987·Critical Care Medicine·D H FiserR Woody
Sep 1, 1984·Neurology·K M Outwater, M A Rockoff
Aug 1, 1996·Critical Care Medicine·E P ChenP Van Trigt
Feb 19, 1999·Circulation Research·H HupfH Schunkert
Mar 20, 1999·Transplantation Proceedings·D K Cooper, M Basker
Apr 19, 2000·Arquivos de neuro-psiquiatria·E D CintraE F Martins

❮ Previous
Next ❯

Citations

Nov 22, 2013·Pediatric Research·Masahiro EnomotoJaques Belik
Dec 23, 2008·Transplantation Proceedings·M Kosieradzki, W Rowiński
Mar 18, 2008·Arquivos de neuro-psiquiatria·Eliane de Araújo CintraRenato G G Terzi
Jan 18, 2020·Scientific Reports·Verónica Viñuela-BerniAndrés Quintanar-Stephano

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.