Vasorelaxant and antiaggregatory properties of the endothelium: a comparative study in normocholesterolaemic and hereditary and dietary hypercholesterolaemic rabbits

British Journal of Pharmacology
C GreenleesR M Wadsworth

Abstract

1. A comparison of the effects of dietary and genetically-induced hypercholesterolaemia on the vasodilator and antiaggregatory capacity of the endothelium was made in rabbit isolated subclavian artery rings. 2. Dietary-induced hypercholesterolaemia in NZW rabbits decreased the maximum relaxation to carbachol (0.01-10 microM) and calcimycin (0.01-0.1 microM) in vessel rings precontracted with 5-hydroxytryptamine (5-HT), 0.1 microM), when compared to responses observed in rings obtained from control normocholesterolaemic NZW rabbits. The relaxant responses to SIN-1 (3-(4-morpholinyl)-sydnonimine hydrochloride) were attenuated but were not significantly different from controls. In Froxfield genetically hypercholesterolaemic (FHH) rabbits, the maximum relaxations to carbachol, calcimycin and SIN-1 were all reduced significantly. 3. Neither genetic nor dietary-induced hypercholesterolaemia modified the contractile responses of vessel rings to either KCl (10-100 mM) or 5-HT (0.01-10 microM). 4. Endothelium-dependent inhibition of collagen-induced platelet aggregation in whole blood was demonstrated by stimulation of a vessel ring, incorporated into the blood sample, with carbachol (10 microM, final blood concentration). This effect w...Continue Reading

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Citations

Aug 7, 2003·Journal of Basic and Clinical Physiology and Pharmacology·Ibrahim BilgenSelma Cirrik
Jun 17, 2004·Journal of Basic and Clinical Physiology and Pharmacology·Mustafa Edremitlioğlu, Gülsen Oner
May 1, 1997·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·H al-ZuhairH A Abd el Latif
Jan 12, 2007·Basic & Clinical Pharmacology & Toxicology·Knut S PetterssonKen M Kengatharan

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