Vasorelaxant effect of opioid analgesics on the isolated human radial artery

European Journal of Anaesthesiology
S GursoyT Kaya

Abstract

Arterial grafts are prone to vasospasm. Opioid analgesics are commonly used in the perioperative course of cardiac surgical procedures. Therefore, we investigated the direct effects of morphine, meperidine, fentanyl and remifentanil on the human radial artery. Radial artery segments, obtained from 20 patients, were precontracted with phenylephrine. Using the organ bath technique, the endothelium-independent vasodilatation was tested in vitro by addition of cumulative concentrations of morphine, meperidine, fentanyl and remifentanil in separate organ baths, in the presence or absence of naloxone. Indomethacin and NG-nitro-L-arginine methyl ester was added to all organ bath in order to determine the effects of prostaglandins and nitric oxide, respectively. Morphine (10(-8) - 10(-4) mol L-1), meperidine (10(-10) - 10(-6) mol L-1), fentanyl (10(-10) - 10(-6) mol L-1) and remifentanil (10(-8) - 10(-4) mol L-1) caused a concentration-dependent vasorelaxation in the human being artery rings. The relaxations in the presence of naloxane did not change. The maximal relaxant effects of meperidine and fentanyl were significantly greater than those of morphine and remifentanil (P < 0.05). These findings indicate that morphine, meperidine, f...Continue Reading

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Citations

Nov 19, 2009·Journal of Anesthesia·Noboru TodaHiroshi Toda
Oct 24, 2007·Peptides·Richard J Bodnar
Oct 26, 2018·Cardiovascular Drugs and Therapy·Marco ZuinLoris Roncon
Apr 16, 2014·Australian Veterinary Journal·R L WilsonR E Doyle
Jan 23, 2016·Anesthesia and Analgesia·José A AguirreMichael Zaugg
Jul 6, 2017·Molecular Medicine Reports·Yan-Fei QianJun-Qiang Si

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