Vasorelaxant properties of the endothelium-derived relaxing factor more closely resemble S-nitrosocysteine than nitric oxide

Nature
P R MyersD G Harrison

Abstract

Studies of cultured bovine aortic endothelial cells using quantitative chemiluminescence techniques have shown that the amount of nitric oxide released under basal conditions, or in response to either bradykinin or the calcium ionophore A23187 is insufficient to account for the vasorelaxant activities of the endothelium-derived relaxing factor (EDRF) derived from the same source. This observation contradicts previous suggestions that nitric oxide and EDRF are the same compound, but may be explained if EDRF is a compound that contains nitric oxide within its structure but is a much more potent vasodilator than nitric oxide. Such a molecule could be one of several nitrosothiols which may yield nitric oxide after a one-electron reduction. The present experiments were carried out to test the possibility that the biological activities of the endothelium-derived relaxing factor might more closely resemble those of one of these compounds, S-nitrosocysteine, than nitric oxide. Nitric oxide release from cultured bovine aortic endothelial cells was detected by chemiluminescence and bioassay experiments compared the vasodilator potencies of nitric oxide, S-nitrosocysteine, and EDRF. The results suggest that EDRF is much more likely to be ...Continue Reading

Citations

Jan 9, 2001·Journal of Cellular Physiology·J X ChenB Meyrick
Jul 15, 1998·Arthritis and Rheumatism·R M ClancyS B Abramson
Aug 1, 1993·Arthritis and Rheumatism·M Stefanovic-RacicC H Evans
Oct 1, 1993·Arthritis and Rheumatism·P F MerrymanS B Abramson
May 1, 1991·Journal of Cellular Biochemistry·G M Rubanyi
Jan 1, 1994·Microsurgery·A G StewartG Grigoriadis
Dec 1, 1993·Naunyn-Schmiedeberg's Archives of Pharmacology·I PörstiR Busse
Sep 1, 1994·Molecular and Cellular Biochemistry·L J McDonald, J Moss
Sep 1, 1994·Digestive Diseases and Sciences·J MurrayJ L Conklin
May 1, 1997·Biulleten' eksperimental'noĭ biologii i meditsiny·K S Raevskiĭ
Oct 1, 1992·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·G Blaise
Oct 1, 1992·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·N R Searle, P Sahab
Sep 18, 2007·Pflügers Archiv : European journal of physiology·D TrigueroA García-Pascual
Feb 15, 2001·Current Hypertension Reports·A WarnholtzT Münzel
Aug 24, 1994·Biochimica Et Biophysica Acta·Y T LauC C Hsieh
Oct 29, 1990·Brain Research·S T MellerG F Gebhart
Jan 10, 1991·European Journal of Pharmacology·D H MauriceR J Haslam
Jun 24, 1993·European Journal of Pharmacology·U C Garg, A Hassid
Feb 14, 1995·European Journal of Pharmacology·K HatakeS Hishida
Feb 11, 1994·European Journal of Pharmacology·C L ZhangJ D Horowitz
May 12, 1994·European Journal of Pharmacology·C M GiraldeloE Antunes
Dec 4, 1995·European Journal of Pharmacology·T NakaharaK Nakayama
Jul 4, 1996·European Journal of Pharmacology·N W Kooy, S J Lewis
Sep 26, 1996·European Journal of Pharmacology·S J LewisJ N Bates
Jul 1, 1996·FEBS Letters·M Kashiba-IwatsukiM Inoue

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.