Abstract
We reported that yam dioscorin and its peptic hydrolysates exhibited ACE inhibition and antihypertensive effects on SHRs, however, the active peptides are not really isolated until now. Using ACE inhibitory screenings, two penta-peptides, KTCGY and KRIHF, were selected for ex vivo and in vivo experiments. KTCGY, KRIHF, and captopril were shown to have similar vasodilating effects against phenylephrine (PE)-induced tensions in rat endothelium-dependent thoracic aortic rings, however, KTCGYKTCGY (two-repeated KTCGY) and TCGYTCGY (two-repeated TCGY) were showed endothelium-independent vasodilating effects against PE-induced tensions. KTCGY, KRIHF (10 or 20 mg/kg), and captopril (10 mg/kg) were used to evaluate antihypertensive activity during 24-h after a single oral administration to spontaneously hypertensive rats (SHRs). The KTCGY and KRIHF showed significantly different and reduced the systolic blood pressure of SHRs compared to the blank. These results suggest that KTCGY and KRIHF may contribute important roles in yam dioscorin for regulating blood pressure in vivo.
References
Nov 1, 1978·Progress in Cardiovascular Diseases·B RubinZ P Horovitz
Jan 1, 1995·Peptides·H FujitaM Yoshikawa
Jun 1, 1995·Plant Molecular Biology·R S ConlanC Ainsworth
Jul 9, 1998·Molecular and Cellular Biochemistry·S Mittra, M Singh
Jul 1, 1999·FEBS Letters·N MatobaM Yoshikawa
Dec 20, 1999·Journal of Agricultural and Food Chemistry·W C HouY H Lin
Jan 11, 2001·Peptides·K S Mark, T P Davis
Oct 16, 2001·Journal of Agricultural and Food Chemistry·W C HouY H Lin
Oct 3, 2002·Journal of Agricultural and Food Chemistry·Feng-Lin HsuWen-Chi Hou
Oct 31, 2002·Nature Reviews. Drug Discovery·Mohammad Amin ZamanDavid A Calhoun
Feb 3, 2005·Journal of Agricultural and Food Chemistry·Blanca Hernández-LedesmaLourdes Amigo
Jul 20, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yen-Wenn LiuWen-Chi Hou
Mar 11, 2008·Life Sciences·Mitsuru TanakaKiyoshi Matsumoto
May 26, 2009·Peptides·Mitsuru TanakaToshiro Matsui
Sep 12, 2009·Journal of Agricultural and Food Chemistry·Yen-Wenn LiuWen-Chi Hou
Aug 7, 2010·Peptides·Zhengquan WangToshiro Matsui
Jan 18, 2012·Food & Function·Daniel Martínez-MaquedaBlanca Hernández-Ledesma
Sep 5, 2012·Molecular Nutrition & Food Research·Tomomi KagebayashiKousaku Ohinata
Feb 16, 2013·Food Chemistry·Chuan-Hsiao HanWen-Chi Hou
Jan 1, 2012·FEBS Open Bio·Yutaro KobayashiToshiro Matsui
Oct 10, 2013·Molecular Nutrition & Food Research·Noriyasu KontaniKousaku Ohinata
Nov 12, 2013·Food Chemistry·Chuan-Hsiao HanWen-Chi Hou
Jan 21, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Chuan-Hsiao HanWen-Chi Hou
Jan 1, 2012·Journal of Traditional and Complementary Medicine·Yeh-Lin LuWen-Chi Hou
Citations
Dec 1, 2015·Botanical Studies·Shen-Liang ShihWen-Chi Hou
Apr 8, 2020·Veterinary World·Yuliana Tandi RubakEndang Prangdimurti
Dec 29, 2017·Journal of Agricultural and Food Chemistry·Guang-Cheng WuWen-Chi Hou
Nov 28, 2017·Journal of Agricultural and Food Chemistry·Zhengquan WangJing Xie
Aug 9, 2016·Journal of Agricultural and Food Chemistry·Yin-Shiou LinWen-Chi Hou