Vasorelaxing effects of flavonoids: investigation on the possible involvement of potassium channels

Naunyn-Schmiedeberg's Archives of Pharmacology
Vincenzo CalderoneE Martinotti

Abstract

A flavonoid-rich diet has been associated with a lower incidence of cardiovascular diseases, probably because of the antioxidant and vasoactive properties of flavonoids. Indeed, many flavonoids show vasorelaxing properties, due to different and often not yet completely clarified mechanisms of action. Among them, the activation of vascular potassium channels has been indicated as a possible pathway, accounting, at least in part, for the vasodilatory action of some flavonoid derivatives, such as apigenin and dioclein. Therefore, this work aims at evaluating, on in vitro isolated rat aortic rings, the endothelium-independent vasorelaxing effects of a number of flavonoid derivatives, to identify a possible activation of calcium-activated and/or ATP-sensitive potassium channels and to indicate some possible structure-activity relationships. Among the several flavonoids submitted to the pharmacological assay, only baicalein and quercetagetin were almost completely ineffective, while quercetin, hesperidin, quercitrin and rhoifolin exhibited only a partial vasorelaxing effect. On the contrary, acacetin, apigenin, chrysin, hesperetin, luteolin, pinocembrin, 4'-hydroxyflavanone, 5-hydroxyflavone, 5-methoxyflavone, 6-hydroxyflavanone and ...Continue Reading

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Citations

Feb 22, 2011·Naunyn-Schmiedeberg's Archives of Pharmacology·Ruijin LiMartin M F Choi
Jul 23, 2013·European Journal of Medicinal Chemistry·Daniela RibeiroEduarda Fernandes
Jul 17, 2012·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Ramesh SrirangamSoumyajit Majumdar
Mar 8, 2012·Circulation Research·Stephanie GuoPaul S Brookes
Apr 23, 2013·European Journal of Nutrition·Hongwei SiDongmin Liu
May 21, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Francisco J Luna-VázquezMiguel Angel Zavala-Sánchez
Jul 26, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Valentina UivarosiStefania Felicia Barbuceanu
Dec 14, 2011·Fitoterapia·François SenejouxCorine Girard-Thernier
Aug 2, 2011·Journal of Molecular Graphics & Modelling·Wilson Maldonado-Rojas, Jesus Olivero-Verbel
Feb 1, 2011·Fitoterapia·D ProcházkováN Wilhelmová
Oct 9, 2008·European Journal of Pharmacology·Smain AmiraFlavia Mulè
Oct 31, 2008·Phytotherapy Research : PTR·Zhenwei PanBaofeng Yang
Apr 19, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Meng GuWen-Juan Tu
Dec 17, 2005·Pharmacology & Therapeutics·Srinivas GhattaStephen T O'Rourke
Apr 22, 2015·European Journal of Pharmacology·Hassiba Benabdallah, Kamel Gharzouli
Jul 13, 2013·Toxicology and Applied Pharmacology·R E RobertsS P H Alexander
Jul 6, 2014·Journal of Ethnopharmacology·ZiHuan YangWenLiang Zhou

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