Abstract
A flavonoid-rich diet has been associated with a lower incidence of cardiovascular diseases, probably because of the antioxidant and vasoactive properties of flavonoids. Indeed, many flavonoids show vasorelaxing properties, due to different and often not yet completely clarified mechanisms of action. Among them, the activation of vascular potassium channels has been indicated as a possible pathway, accounting, at least in part, for the vasodilatory action of some flavonoid derivatives, such as apigenin and dioclein. Therefore, this work aims at evaluating, on in vitro isolated rat aortic rings, the endothelium-independent vasorelaxing effects of a number of flavonoid derivatives, to identify a possible activation of calcium-activated and/or ATP-sensitive potassium channels and to indicate some possible structure-activity relationships. Among the several flavonoids submitted to the pharmacological assay, only baicalein and quercetagetin were almost completely ineffective, while quercetin, hesperidin, quercitrin and rhoifolin exhibited only a partial vasorelaxing effect. On the contrary, acacetin, apigenin, chrysin, hesperetin, luteolin, pinocembrin, 4'-hydroxyflavanone, 5-hydroxyflavone, 5-methoxyflavone, 6-hydroxyflavanone and ...Continue Reading
References
Aug 1, 1995·Naunyn-Schmiedeberg's Archives of Pharmacology·J L BalwierczakS Hu
Mar 1, 1995·Cardiovascular Drugs and Therapy·I CaveroJ M Guillon
Oct 23, 1993·Lancet·M G HertogD Kromhout
Jul 1, 1993·General Pharmacology·J DuarteA Zarzuelo
Feb 24, 1996·BMJ : British Medical Journal·P KnektJ Maatela
Mar 1, 1996·General Pharmacology·M D HerreraJ Duarte
Feb 1, 1997·British Journal of Pharmacology·C Löffler, U Quast
Aug 7, 1998·Atherosclerosis·M Aviram, B Fuhrman
Nov 24, 1998·Naunyn-Schmiedeberg's Archives of Pharmacology·M MagnonI Cavero
Apr 8, 1999·British Journal of Pharmacology·E C Chan, O L Woodman
Nov 22, 2000·American Journal of Physiology. Heart and Circulatory Physiology·S G Clark, L C Fuchs
Feb 7, 2001·Circulation Research·J MarijicL Toro
Jul 17, 2001·British Journal of Pharmacology·S F CôrtesV S Lemos
Jul 23, 2002·Current Medicinal Chemistry·V Calderone
Apr 2, 2003·Bioorganic & Medicinal Chemistry Letters·Yi LiJohn E Starrett
Dec 4, 2003·Planta medica·Antonio NardiIvano Morelli
Jan 6, 2004·Medicinal Research Reviews·Raimund Mannhold
Citations
Dec 16, 2004·Naunyn-Schmiedeberg's Archives of Pharmacology·Francisco OralloClaire Lugnier
Jan 5, 2007·Naunyn-Schmiedeberg's Archives of Pharmacology·Vincenzo CalderoneMaria C Breschi
Feb 22, 2011·Naunyn-Schmiedeberg's Archives of Pharmacology·Ruijin LiMartin M F Choi
Apr 10, 2013·Biochemical Pharmacology·L TestaiV Calderone
Jul 23, 2013·European Journal of Medicinal Chemistry·Daniela RibeiroEduarda Fernandes
Jan 10, 2014·Talanta·Ahmad Abo Markeb, Nagwa Abo El-Maali
Jul 17, 2012·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Ramesh SrirangamSoumyajit Majumdar
Mar 8, 2012·Circulation Research·Stephanie GuoPaul S Brookes
Apr 5, 2008·Journal of Nutritional Science and Vitaminology·Masaki YamamotoTadashi Hase
Apr 23, 2013·European Journal of Nutrition·Hongwei SiDongmin Liu
May 21, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Francisco J Luna-VázquezMiguel Angel Zavala-Sánchez
Jul 26, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Valentina UivarosiStefania Felicia Barbuceanu
May 29, 2012·FEBS Letters·Shingo MiyataRyuichiro Sato
Apr 25, 2013·Biochemical and Biophysical Research Communications·Li LiGuan-Hua Du
Jul 30, 2015·Biopharmaceutics & Drug Disposition·Tomohide UnoHiromasa Imaishi
Dec 14, 2011·Fitoterapia·François SenejouxCorine Girard-Thernier
Aug 2, 2011·Journal of Molecular Graphics & Modelling·Wilson Maldonado-Rojas, Jesus Olivero-Verbel
Apr 29, 2011·Diabetes Research and Clinical Practice·Jong-Hoon KimHyunsu Bae
Feb 1, 2011·Fitoterapia·D ProcházkováN Wilhelmová
May 12, 2009·Life Sciences·Alessandra RotondoFlavia Mulè
Nov 4, 2008·Biophysical Chemistry·Sudip ChaudhuriPradeep K Sengupta
Oct 9, 2008·European Journal of Pharmacology·Smain AmiraFlavia Mulè
Feb 13, 2007·Journal of Ethnopharmacology·Moonkyu KangHyunsu Bae
Mar 15, 2016·Chemico-biological Interactions·Neha RaniDharamvir Singh Arya
Oct 31, 2015·Journal of Natural Products·Sara MerloAgata Copani
May 10, 2007·Journal of Thrombosis and Haemostasis : JTH·A ErdoganC R W Kuhlmann
Mar 16, 2006·The Journal of Pharmacy and Pharmacology·Wilfried Dimpfel
Nov 8, 2006·British Journal of Pharmacology·S SaponaraV Calderone
Oct 31, 2008·Phytotherapy Research : PTR·Zhenwei PanBaofeng Yang
Apr 19, 2013·Journal of Applied Microbiology·L W SoromouD Wang
Apr 23, 2013·The Journal of Pharmacy and Pharmacology·Lara TestaiVincenzo Calderone
Apr 19, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Meng GuWen-Juan Tu
May 19, 2009·Biochemical Pharmacology·Oswaldo Hernández-AbreuSamuel Estrada-Soto
Nov 1, 2006·Vascular Pharmacology·Xiao-Ming ZhuGuan-Hua Du
Dec 17, 2005·Pharmacology & Therapeutics·Srinivas GhattaStephen T O'Rourke
Apr 16, 2014·Biomedical Chromatography : BMC·Bei YanYingfa Liu
Apr 22, 2015·European Journal of Pharmacology·Hassiba Benabdallah, Kamel Gharzouli
Dec 13, 2012·Neuropharmacology·Rui LiuGuan-hua Du
May 27, 2015·Life Sciences·Lara Testai
May 24, 2013·Journal of Immunotoxicology·Lanan Wassy SoromouHaihua Feng
Mar 17, 2015·Nutrition & Metabolism·Neha RaniDharamvir Singh Arya
Feb 25, 2015·Pharmacognosy Magazine·S TakırB S Uydeş-Doǧan
Nov 18, 2010·Biochimie·Zhu DeqiuLiu Gaolin
Jul 13, 2013·Toxicology and Applied Pharmacology·R E RobertsS P H Alexander
Apr 23, 2014·European Journal of Pharmacology·Yu LiuMingsheng Zhang
Jul 6, 2014·Journal of Ethnopharmacology·ZiHuan YangWenLiang Zhou
Jan 28, 2015·Life Sciences·Ali RoohbakhshMehrdad Iranshahi
Jun 3, 2016·Pharmaceutical Biology·Angélica Flores-FloresSamuel Estrada-Soto
Jul 2, 2016·Phytotherapy Research : PTR·Lukáš DobiašViera Kristová
Jul 12, 2016·European Journal of Pharmacology·Huan WangQiang Tang