PMID: 37701Jan 1, 1979

Vasospastic phenomena in patients treated with beta-adrenoceptor blocking agents

Acta Medica Scandinavica. Supplementum
K EliassonK Sundqvist


Twenty-one patients developed Raynaud's phenomenon during treatment with beta-adrenoceptor blocking agents. The vasospastic symptoms were obviously related to the treatment, but their pathogenesis is still controversial. A decrease in cardiac output might explain the phenomenon. According to our very preliminary data an alpha-adrenergic dominance caused by a direct effect on the peripheral circulation seems more probable. Vasospastic symptoms may arise after treatment with both cardioselective and non-selective beta blocking agents. Cautious prescription of beta blocking drugs to patients with preexisting peripheral vascular disease is recommended.


Jan 1, 1976·Acta Medica Scandinavica·L HanssonN C Henningsen
May 8, 1976·British Medical Journal·J C RodgerW R Livingstone
Jun 19, 1976·British Medical Journal·A J MarshallD W Barritt
Apr 16, 1977·British Medical Journal·C L van HerwaardenA van t'Laar
Sep 1, 1975·Progress in Cardiovascular Diseases·J D Coffman, W T Davies
Dec 4, 1971·Lancet·H J Waal-Manning, F O Simpson
Feb 1, 1973·Life Sciences. Pt. 1: Physiology and Pharmacology·B AbladL Ek
Jan 1, 1974·Advances in Cardiology·B AbladE Hultberg
Jul 1, 1972·Proceedings of the Society for Experimental Biology and Medicine·S JuliusR London
Jul 1, 1974·The Journal of Physiology·B EklundE Knutsson
Jul 29, 1971·The New England Journal of Medicine·J D Coffman, A S Cohen
Jan 4, 1969·British Medical Journal·B N Prichard, P M Gillam


Related Concepts

Adrenergic beta-Antagonists
Alprenolol Hydrochloride
Blood Circulation
Cardiac Output
Hypertensive Disease
Raynaud Phenomenon

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